Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
Uremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with...
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/10/1239 |
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| author | Ping-Hsun Lu Chien-Cheng Lai I-Hsin Lin Fu-Ming Tsai Po-Hsuan Lu |
| author_facet | Ping-Hsun Lu Chien-Cheng Lai I-Hsin Lin Fu-Ming Tsai Po-Hsuan Lu |
| author_sort | Ping-Hsun Lu |
| collection | DOAJ |
| description | Uremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with uremic pruritus. We searched databases (prior to 3 May 2022) for randomized controlled trials on the effects of Chinese herbal medicine in treating uremic pruritus. Our meta-analysis included 3311 patients from 50 randomized controlled trials. In patients with uremic pruritus, adjunctive Chinese herbal medicine significantly improved overall effectiveness (risk ratio 1.29, 95% CI 1.23 to 1.35), quality of life, renal function, reduced pruritus score, and inflammatory biomarkers compared to control groups with hemodialysis alone or with anti-pruritic treatments. Chinese herbal medicine treatment showed a time-dependent tendency in improving the visual analog scale of dialysis patients. Compared to control groups, no significantly higher risk of adverse events in patients taking Chinese herbal medicine (risk ratio 0.60, 95% CI 0.22 to 1.63). Chinese herbal medicine appears to be effective and safe in complementing the treatment of patients with uremic pruritus. |
| first_indexed | 2024-03-09T19:36:45Z |
| format | Article |
| id | doaj.art-a3460db685684f6688f5247494cbcdff |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a3460db685684f6688f5247494cbcdff2023-11-24T01:51:40ZengMDPI AGPharmaceuticals1424-82472022-10-011510123910.3390/ph15101239Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled TrialsPing-Hsun Lu0Chien-Cheng Lai1I-Hsin Lin2Fu-Ming Tsai3Po-Hsuan Lu4Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, TaiwanDepartment of Medical Education, MacKay Memorial Hospital, Taipei 10449, TaiwanSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97048, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, TaiwanDepartment of Dermatology, MacKay Memorial Hospital, Taipei 10449, TaiwanUremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with uremic pruritus. We searched databases (prior to 3 May 2022) for randomized controlled trials on the effects of Chinese herbal medicine in treating uremic pruritus. Our meta-analysis included 3311 patients from 50 randomized controlled trials. In patients with uremic pruritus, adjunctive Chinese herbal medicine significantly improved overall effectiveness (risk ratio 1.29, 95% CI 1.23 to 1.35), quality of life, renal function, reduced pruritus score, and inflammatory biomarkers compared to control groups with hemodialysis alone or with anti-pruritic treatments. Chinese herbal medicine treatment showed a time-dependent tendency in improving the visual analog scale of dialysis patients. Compared to control groups, no significantly higher risk of adverse events in patients taking Chinese herbal medicine (risk ratio 0.60, 95% CI 0.22 to 1.63). Chinese herbal medicine appears to be effective and safe in complementing the treatment of patients with uremic pruritus.https://www.mdpi.com/1424-8247/15/10/1239uremic prurituschronic kidney diseasechronic renal failureChinese herbal medicinesystematic reviewmeta-analysis |
| spellingShingle | Ping-Hsun Lu Chien-Cheng Lai I-Hsin Lin Fu-Ming Tsai Po-Hsuan Lu Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials Pharmaceuticals uremic pruritus chronic kidney disease chronic renal failure Chinese herbal medicine systematic review meta-analysis |
| title | Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials |
| title_full | Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials |
| title_short | Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials |
| title_sort | clinical efficacy and safety of chinese herbal medicine in the treatment of uremic pruritus a meta analysis of randomized controlled trials |
| topic | uremic pruritus chronic kidney disease chronic renal failure Chinese herbal medicine systematic review meta-analysis |
| url | https://www.mdpi.com/1424-8247/15/10/1239 |
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