Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study
<h4>Background</h4> Many studies have assessed the association between anemia and mortality in hemodialysis but few compared patients with and without diabetes. Our study aims to investigate the impact of hemoglobin and iron parameters on mortality in hemodialysis patients with or withou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888689/?tool=EBI |
| _version_ | 1811173555811909632 |
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| author | Jihane Asmar Dania Chelala Razane El Hajj Chehade Hiba Azar Serge Finianos Mabel Aoun |
| author_facet | Jihane Asmar Dania Chelala Razane El Hajj Chehade Hiba Azar Serge Finianos Mabel Aoun |
| author_sort | Jihane Asmar |
| collection | DOAJ |
| description | <h4>Background</h4> Many studies have assessed the association between anemia and mortality in hemodialysis but few compared patients with and without diabetes. Our study aims to investigate the impact of hemoglobin and iron parameters on mortality in hemodialysis patients with or without diabetes. <h4>Methods</h4> This is a two-center retrospective study that included all adult patients who started hemodialysis between February 2012 and February 2020, followed until January 2021. Averages of hemoglobin, ferritin and transferrin saturation of entire follow-up were recorded. Kaplan Meier survival, log rank test and cox regression analyses were performed to assess the association between anemia biomarkers and mortality. <h4>Results</h4> A total of 214 patients were included. Mean age was 67.98 ±12.41 years, mean hemoglobin was 10.92 ±0.75 g/dL, mean ferritin was 504.43 ± 221.42 ng/mL and mean transferrin saturation was 26.23 ±7.77%. Log rank test showed an association between hemoglobin ≥11 g/dL and better survival in patients without diabetes (P = 0.028). Based on cox regression analysis, hemoglobin was associated with all-cause mortality in all patients (HR = 0.66; CI:0.49,0.89; P = 0.007). When comparing patients with and without diabetes, this association remained significant only in patients without diabetes (HR = 0.53; CI:0.37,0.77; P<0.001). Based on different multivariate models, hemoglobin, ferritin and age were independent factors associated with mortality in patients without diabetes. <h4>Conclusions</h4> This study showed that hemoglobin ≥11 g/dL is associated with better survival in hemodialysis patients without diabetes but not in those with diabetes. These differences need to be further explored in other countries and settings. An individualization of the hemoglobin target level might be necessary to improve patients’ outcomes. |
| first_indexed | 2024-04-10T17:48:55Z |
| format | Article |
| id | doaj.art-a346ab90b6234227a972506f06b3d2c0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T17:48:55Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a346ab90b6234227a972506f06b3d2c02023-02-02T22:58:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up studyJihane AsmarDania ChelalaRazane El Hajj ChehadeHiba AzarSerge FinianosMabel Aoun<h4>Background</h4> Many studies have assessed the association between anemia and mortality in hemodialysis but few compared patients with and without diabetes. Our study aims to investigate the impact of hemoglobin and iron parameters on mortality in hemodialysis patients with or without diabetes. <h4>Methods</h4> This is a two-center retrospective study that included all adult patients who started hemodialysis between February 2012 and February 2020, followed until January 2021. Averages of hemoglobin, ferritin and transferrin saturation of entire follow-up were recorded. Kaplan Meier survival, log rank test and cox regression analyses were performed to assess the association between anemia biomarkers and mortality. <h4>Results</h4> A total of 214 patients were included. Mean age was 67.98 ±12.41 years, mean hemoglobin was 10.92 ±0.75 g/dL, mean ferritin was 504.43 ± 221.42 ng/mL and mean transferrin saturation was 26.23 ±7.77%. Log rank test showed an association between hemoglobin ≥11 g/dL and better survival in patients without diabetes (P = 0.028). Based on cox regression analysis, hemoglobin was associated with all-cause mortality in all patients (HR = 0.66; CI:0.49,0.89; P = 0.007). When comparing patients with and without diabetes, this association remained significant only in patients without diabetes (HR = 0.53; CI:0.37,0.77; P<0.001). Based on different multivariate models, hemoglobin, ferritin and age were independent factors associated with mortality in patients without diabetes. <h4>Conclusions</h4> This study showed that hemoglobin ≥11 g/dL is associated with better survival in hemodialysis patients without diabetes but not in those with diabetes. These differences need to be further explored in other countries and settings. An individualization of the hemoglobin target level might be necessary to improve patients’ outcomes.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888689/?tool=EBI |
| spellingShingle | Jihane Asmar Dania Chelala Razane El Hajj Chehade Hiba Azar Serge Finianos Mabel Aoun Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study PLoS ONE |
| title | Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study |
| title_full | Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study |
| title_fullStr | Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study |
| title_full_unstemmed | Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study |
| title_short | Anemia biomarkers and mortality in hemodialysis patients with or without diabetes: A 10-year follow-up study |
| title_sort | anemia biomarkers and mortality in hemodialysis patients with or without diabetes a 10 year follow up study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888689/?tool=EBI |
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