Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade
Natural compounds, known for diverse pharmacological properties, have attracted attention as potential sources for hypertension treatment. Previous studies have revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from <i>Prunus yedoensis</i>. H...
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/2/346 |
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| author | Sujin Shin Junkyu Park Ho-Young Choi Youngmin Bu Kyungjin Lee |
| author_facet | Sujin Shin Junkyu Park Ho-Young Choi Youngmin Bu Kyungjin Lee |
| author_sort | Sujin Shin |
| collection | DOAJ |
| description | Natural compounds, known for diverse pharmacological properties, have attracted attention as potential sources for hypertension treatment. Previous studies have revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from <i>Prunus yedoensis</i>. However, the potential blood pressure-lowering and vasorelaxant effects of sakuranetin, another representative compound found in plants belonging to the genus <i>Prunus</i>, have remained unexplored. We aimed to fill this gap by investigating the hypotensive and vasorelaxant effects of sakuranetin in rats. Results indicated that sakuranetin, particularly in the sakuranetin 20 mg/kg group, led to significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) by −14.53 ± 5.64% and −19.83 ± 6.56% at 4 h after administration. In the sakuranetin 50 mg/kg group, the SBP and DBP decreased by −13.27 ± 6.86% and −16.62 ± 10.01% at 2 h and by −21.61 ± 4.49% and −30.45 ± 5.21% at 4 h after administration. In addition, we identified the vasorelaxant effects of sakuranetin, attributing its mechanisms to the inhibition of calcium influx and the modulation of angiotensin II. Considering its hypotensive and vasorelaxant effects, sakuranetin could potentially serve as an antihypertensive agent. However, further research is required to evaluate the safety and long-term efficacy. |
| first_indexed | 2024-03-07T22:41:53Z |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-07T22:41:53Z |
| publishDate | 2024-02-01 |
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| series | Biomedicines |
| spelling | doaj.art-a3476314a7f849bc821c106a7fdcf2352024-02-23T15:08:33ZengMDPI AGBiomedicines2227-90592024-02-0112234610.3390/biomedicines12020346Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel BlockadeSujin Shin0Junkyu Park1Ho-Young Choi2Youngmin Bu3Kyungjin Lee4Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaNatural compounds, known for diverse pharmacological properties, have attracted attention as potential sources for hypertension treatment. Previous studies have revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from <i>Prunus yedoensis</i>. However, the potential blood pressure-lowering and vasorelaxant effects of sakuranetin, another representative compound found in plants belonging to the genus <i>Prunus</i>, have remained unexplored. We aimed to fill this gap by investigating the hypotensive and vasorelaxant effects of sakuranetin in rats. Results indicated that sakuranetin, particularly in the sakuranetin 20 mg/kg group, led to significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) by −14.53 ± 5.64% and −19.83 ± 6.56% at 4 h after administration. In the sakuranetin 50 mg/kg group, the SBP and DBP decreased by −13.27 ± 6.86% and −16.62 ± 10.01% at 2 h and by −21.61 ± 4.49% and −30.45 ± 5.21% at 4 h after administration. In addition, we identified the vasorelaxant effects of sakuranetin, attributing its mechanisms to the inhibition of calcium influx and the modulation of angiotensin II. Considering its hypotensive and vasorelaxant effects, sakuranetin could potentially serve as an antihypertensive agent. However, further research is required to evaluate the safety and long-term efficacy.https://www.mdpi.com/2227-9059/12/2/346sakuranetinnatural compoundblood pressurehypertensioncardiovascular diseasevasorelaxation |
| spellingShingle | Sujin Shin Junkyu Park Ho-Young Choi Youngmin Bu Kyungjin Lee Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade Biomedicines sakuranetin natural compound blood pressure hypertension cardiovascular disease vasorelaxation |
| title | Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade |
| title_full | Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade |
| title_fullStr | Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade |
| title_full_unstemmed | Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade |
| title_short | Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade |
| title_sort | sakuranetin as a potential regulator of blood pressure in spontaneously hypertensive rats by promoting vasorelaxation through calcium channel blockade |
| topic | sakuranetin natural compound blood pressure hypertension cardiovascular disease vasorelaxation |
| url | https://www.mdpi.com/2227-9059/12/2/346 |
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