Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail
Targeted and immunotherapy have revolutionized cancer treatment. They safely substitute for traditional chemotherapy in a significant and growing number of malignancies. In this article, we review the United States Food and Drug Administration (FDA) - approved targeted and immunotherapies, currently...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia
2021-10-01
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| Series: | Brazilian Journal of Oncology |
| Subjects: | |
| Online Access: | http://www.brazilianjournalofoncology.com.br/details/162/en-US/immune-and-targeted-therapy-for-cancer--time-to-rethink-restrictions-for-the-treatment-of-the-elderly-and-frail |
| _version_ | 1827807064527732736 |
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| author | Juliana Rodrigues Beal Gustavo Schvartsman Rodrigo Ramella Munhoz Theodora Karnakis Rafael Aliosha Kaliks |
| author_facet | Juliana Rodrigues Beal Gustavo Schvartsman Rodrigo Ramella Munhoz Theodora Karnakis Rafael Aliosha Kaliks |
| author_sort | Juliana Rodrigues Beal |
| collection | DOAJ |
| description | Targeted and immunotherapy have revolutionized cancer treatment. They safely substitute for traditional chemotherapy in a significant and growing number of malignancies. In this article, we review the United States Food and Drug Administration (FDA) - approved targeted and immunotherapies, currently used in oncology and compare their safety and efficacy in young versus geriatric and frail sub-population. The results suggest an overall comparable, if not superior efficacy in several tumor types, with acceptable toxicities across the board compared to cytotoxic chemotherapy and a favorable analysis in the comparison to the results observed in the younger population. The very decision to place elderly patients on exclusive palliative care can no longer be supported based on age or frailty alone. The historical concept of medical oncologists leaning for palliative treatments for these patients needs to be revisited. |
| first_indexed | 2024-03-11T21:51:40Z |
| format | Article |
| id | doaj.art-a3478851c8a44cf0873fb3b8d3e71c2c |
| institution | Directory Open Access Journal |
| issn | 2526-8732 |
| language | English |
| last_indexed | 2024-03-11T21:51:40Z |
| publishDate | 2021-10-01 |
| publisher | Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj.art-a3478851c8a44cf0873fb3b8d3e71c2c2023-09-26T09:00:16ZengSociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de RadioterapiaBrazilian Journal of Oncology2526-87322021-10-01170010.5935/2526-8732.20210015Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frailJuliana Rodrigues Beal0Gustavo Schvartsman1https://orcid.org/0000-0001-6601-3726Rodrigo Ramella Munhoz2Theodora Karnakis3Rafael Aliosha Kaliks4Hospital Israelita Albert Einstein, Medical Oncology - São Paulo - SP - BrazilHospital Israelita Albert Einstein, Medical Oncology - São Paulo - SP - BrazilHospital Sírio-Libanes, Medical Oncology - São Paulo - SP - BrazilUniversidade de São Paulo, Geriatrics - São Paulo - SP - BrazilHospital Israelita Albert Einstein, Medical Oncology - São Paulo - SP - BrazilTargeted and immunotherapy have revolutionized cancer treatment. They safely substitute for traditional chemotherapy in a significant and growing number of malignancies. In this article, we review the United States Food and Drug Administration (FDA) - approved targeted and immunotherapies, currently used in oncology and compare their safety and efficacy in young versus geriatric and frail sub-population. The results suggest an overall comparable, if not superior efficacy in several tumor types, with acceptable toxicities across the board compared to cytotoxic chemotherapy and a favorable analysis in the comparison to the results observed in the younger population. The very decision to place elderly patients on exclusive palliative care can no longer be supported based on age or frailty alone. The historical concept of medical oncologists leaning for palliative treatments for these patients needs to be revisited.http://www.brazilianjournalofoncology.com.br/details/162/en-US/immune-and-targeted-therapy-for-cancer--time-to-rethink-restrictions-for-the-treatment-of-the-elderly-and-frailmolecular targeted therapyimmunotherapytherapeuticsfrail elderlyaged |
| spellingShingle | Juliana Rodrigues Beal Gustavo Schvartsman Rodrigo Ramella Munhoz Theodora Karnakis Rafael Aliosha Kaliks Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail Brazilian Journal of Oncology molecular targeted therapy immunotherapy therapeutics frail elderly aged |
| title | Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail |
| title_full | Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail |
| title_fullStr | Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail |
| title_full_unstemmed | Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail |
| title_short | Immune and targeted therapy for cancer: time to rethink restrictions for the treatment of the elderly and frail |
| title_sort | immune and targeted therapy for cancer time to rethink restrictions for the treatment of the elderly and frail |
| topic | molecular targeted therapy immunotherapy therapeutics frail elderly aged |
| url | http://www.brazilianjournalofoncology.com.br/details/162/en-US/immune-and-targeted-therapy-for-cancer--time-to-rethink-restrictions-for-the-treatment-of-the-elderly-and-frail |
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