Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways
Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The current research aimed to evaluate the antias...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-12-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2022-0038 |
| _version_ | 1797832505177407488 |
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| author | Yu Li Li Jianying |
| author_facet | Yu Li Li Jianying |
| author_sort | Yu Li |
| collection | DOAJ |
| description | Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The current research aimed to evaluate the antiasthmatic effects of punicalagin in an ovalbumin (OVA)-induced experimental model of asthma in female BALB/c mice. Treatment group animals received punicalagin (12.5, 25 or 50 mg kg−1 body mass) per day for 21 days from day 1 of OVA injection. Dexamethasone (DEX) was administered to a separate group of mice, as the standard drug control. Inflammatory cell infiltration into the broncho-alveolar lavage fluid (BALF) was substantially decreased in punicalagin-treated mice. Punicalagin reduced Th2-derived cytokines and OVA-specific IgE levels. The IL-4/STAT6 and Notch/GATA3 signalling pathways were regulated on punicalagin administration. The data obtained illustrate the potency of punicalagin as an anti-asthmatic drug. Conclusively, the study’s observations suggest the potential therapeutic efficiency of punicalagin in allergic asthma. |
| first_indexed | 2024-04-09T14:09:02Z |
| format | Article |
| id | doaj.art-a3482c1a426d49898923d1bc4c2f6af7 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-04-09T14:09:02Z |
| publishDate | 2022-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-a3482c1a426d49898923d1bc4c2f6af72023-05-06T15:50:45ZengSciendoActa Pharmaceutica1846-95582022-12-0172456157310.2478/acph-2022-0038Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathwaysYu Li0Li Jianying1Department of the division of general medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaDepartment of the division of general medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaAllergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The current research aimed to evaluate the antiasthmatic effects of punicalagin in an ovalbumin (OVA)-induced experimental model of asthma in female BALB/c mice. Treatment group animals received punicalagin (12.5, 25 or 50 mg kg−1 body mass) per day for 21 days from day 1 of OVA injection. Dexamethasone (DEX) was administered to a separate group of mice, as the standard drug control. Inflammatory cell infiltration into the broncho-alveolar lavage fluid (BALF) was substantially decreased in punicalagin-treated mice. Punicalagin reduced Th2-derived cytokines and OVA-specific IgE levels. The IL-4/STAT6 and Notch/GATA3 signalling pathways were regulated on punicalagin administration. The data obtained illustrate the potency of punicalagin as an anti-asthmatic drug. Conclusively, the study’s observations suggest the potential therapeutic efficiency of punicalagin in allergic asthma.https://doi.org/10.2478/acph-2022-0038asthmagata3inflammationinterleukinsnotch signalpunicalagin |
| spellingShingle | Yu Li Li Jianying Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways Acta Pharmaceutica asthma gata3 inflammation interleukins notch signal punicalagin |
| title | Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways |
| title_full | Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways |
| title_fullStr | Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways |
| title_full_unstemmed | Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways |
| title_short | Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways |
| title_sort | punicalagin attenuated allergic airway inflammation via regulating il4 il 4rα stat6 and notch gata3 pathways |
| topic | asthma gata3 inflammation interleukins notch signal punicalagin |
| url | https://doi.org/10.2478/acph-2022-0038 |
| work_keys_str_mv | AT yuli punicalaginattenuatedallergicairwayinflammationviaregulatingil4il4rastat6andnotchgata3pathways AT lijianying punicalaginattenuatedallergicairwayinflammationviaregulatingil4il4rastat6andnotchgata3pathways |