Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells.

Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells.

Epstein-Barr virus (EBV) and Plasmodium falciparum have a well described role in the development of endemic Burkitt lymphoma (BL), yet the mechanisms involved remain unknown. A major hallmark of malarial disease is hemolysis and bystander eryptosis of red blood cells, which causes release of free he...

Full description

Bibliographic Details
Main Authors:	Anna M Burnet, Tonya Brunetti, Rosemary Rochford
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-08-01
Series:	PLoS Pathogens
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011561&type=printable

Similar Items

Targeting latent viral infection in EBV-associated lymphomas
by: Isabella Y. Kong, et al.
Published: (2024-02-01)

Spontaneous EBV-Reactivation during B Cell Differentiation as a Model for Polymorphic EBV-Driven Lymphoproliferation
by: Matthew A. Care, et al.
Published: (2023-06-01)

Radiation-induced Epstein–Barr virus reactivation in gastric cancer cells with latent EBV infection
by: Athira Nandakumar, et al.
Published: (2017-06-01)

Arsenic trioxide inhibits EBV reactivation and promotes cell death in EBV-positive lymphoma cells
by: Qinyan Yin, et al.
Published: (2017-06-01)

Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation.
by: Samaresh Malik, et al.
Published: (2024-03-01)

EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency.
by: Christine T Styles, et al.
Published: (2017-08-01)

Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9
by: Hirashima Mitsuomi, et al.
Published: (2006-12-01)

Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis
by: Deborah Rudin, et al.
Published: (2020-07-01)

Establishment of Epstein–Barr Virus (EBV) Latent Gene-Expressing T-Cell Lines with an Expression Vector Harboring EBV Nuclear Antigen 1
by: Hiroyuki Kanno, et al.
Published: (2023-10-01)

Viral particles drive rapid differentiation of memory B cells into secondary plasma cells producing increased levels of antibodies.
by: Zabel, F, et al.
Published: (2014)

Viral Particles Drive Rapid Differentiation of Memory B Cells into Secondary Plasma Cells Producing Increased Levels of Antibodies
by: Zabel, F, et al.
Published: (2014)

Interaction between Hemin and Prion Peptides: Binding, Oxidative Reactivity and Aggregation
by: Simone Dell’Acqua, et al.
Published: (2020-10-01)

EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas.
by: Kathy H Y Shair, et al.
Published: (2007-11-01)

Epstein-Barr Virus (EBV) Is Mostly Latent and Clonal in Angioimmunoblastic T Cell Lymphoma (AITL)
by: Racha Bahri, et al.
Published: (2022-06-01)

Emergence of CD4+ and CD8+ Polyfunctional T Cell Responses Against Immunodominant Lytic and Latent EBV Antigens in Children With Primary EBV Infection
by: Janice K. P. Lam, et al.
Published: (2018-03-01)

Epstein-Barr virus (EBV) Rta-mediated EBV and Kaposi's sarcoma-associated herpesvirus lytic reactivations in 293 cells.
by: Yen-Ju Chen, et al.
Published: (2011-03-01)

Aesthetics and Hemin's Poetry
by: Jafar Ghahramany, et al.
Published: (2017-12-01)

S291: LONG-TERM SAFETY AND EFFICACY OF CMV/EBV-SPECIFIC T CELLS FOR CMV AND EBV CO-REACTIVATION AFTER HAPLOIDENTICAL STEM CELL TRANSPLANTATION
by: Pei Xuying, et al.
Published: (2023-08-01)

Hemin_Induced Changes in the Red Blood Cell Membrane Structure
by: V. V. Moroz, et al.
Published: (2012-12-01)

Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells.
by: Chiara Rancan, et al.
Published: (2015-06-01)

Updates on Epstein–Barr Virus (EBV)-Associated Nasopharyngeal Carcinoma: Emphasis on the Latent Gene Products of EBV
by: Naveed Ahmed, et al.
Published: (2022-12-01)

From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity
by: Darja Kanduc, et al.
Published: (2020-08-01)

Profiling viral and host microRNA expression in cells infected with KSHV and EBV
by: Yarchoan R, et al.
Published: (2009-06-01)

Impact of Hemin on Interleukin-21 Levels and Plasma Cells in Transfusion-Dependent Thalassemia with Positive and Negative Allo-Autoantibody
by: Tambunan BA, et al.
Published: (2023-01-01)

Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma
by: Rosemary Rochford
Published: (2016-01-01)

Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
by: J Luis Espinoza, et al.
Published: (2012-01-01)

An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation.
by: Yonggang Pei, et al.
Published: (2017-07-01)

The Role of NK Cells in EBV Infection and EBV-Associated NPC
by: Yi Tian Png, et al.
Published: (2021-02-01)

EBV-induced T-cell responses in EBV-specific and nonspecific cancers
by: Qiuting Zhang, et al.
Published: (2023-09-01)

MiR-27a Promotes Hemin-Induced Erythroid Differentiation of K562 Cells by Targeting CDC25B
by: Dongsheng Wang, et al.
Published: (2018-03-01)

A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.
by: Jessica M Conway, et al.
Published: (2011-04-01)

HCMV protein LUNA is required for viral reactivation from latently infected primary CD14⁺ cells.
by: Lisa R Keyes, et al.
Published: (2012-01-01)

Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells
by: Chung-Chun Wu, et al.
Published: (2018-04-01)

Glutathione–Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells’ Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis
by: Sofia K. Georgiou-Siafis, et al.
Published: (2022-09-01)

The Porphyromonas gingivalis ferric uptake regulator orthologue binds hemin and regulates hemin-responsive biofilm development.
by: Catherine A Butler, et al.
Published: (2014-01-01)

Macrophages drive KSHV B cell latency
by: Agnieszka Szymula, et al.
Published: (2023-07-01)

Unexpected instability of family of repeats (FR), the critical cis-acting sequence required for EBV latent infection, in EBV-BAC systems.
by: Teru Kanda, et al.
Published: (2011-01-01)

PP 4.5 – 00064 Differentiation Enhances Reactivation of Latent HIV-1 Reservoir in CD4+ T Cells in PLWH With > 4 Years of Viral Suppression
by: Y. Kuzmichev, et al.
Published: (2022-12-01)

Correction: HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14+ Cells
Published: (2013-01-01)

Correction: HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14 Cells.
by: Lisa R. Keyes, et al.
Published: (2013-01-01)