Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease
Abstract Introduction Hyperuricemia and diabetes mellitus (DM) are associated with increased mortality risk in patients with chronic kidney disease (CKD). Here we aimed to evaluate the independent and joint risks of these two conditions on mortality and end stage kidney disease (ESKD) in CKD-patient...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-022-02755-1 |
| _version_ | 1818060598230908928 |
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| author | Cheng-Hung Li Chia-Lin Lee Yu-Cheng Hsieh Cheng-Hsu Chen Ming-Ju Wu Shang-Feng Tsai |
| author_facet | Cheng-Hung Li Chia-Lin Lee Yu-Cheng Hsieh Cheng-Hsu Chen Ming-Ju Wu Shang-Feng Tsai |
| author_sort | Cheng-Hung Li |
| collection | DOAJ |
| description | Abstract Introduction Hyperuricemia and diabetes mellitus (DM) are associated with increased mortality risk in patients with chronic kidney disease (CKD). Here we aimed to evaluate the independent and joint risks of these two conditions on mortality and end stage kidney disease (ESKD) in CKD-patients. Methods This retrospective cohort study enrolled 4380 outpatients (with CKD stage 3–5) with mortality and ESKD linkage during a 7-year period (from 2007 to 2013). All-causes mortality and ESKD risks were analyzed by multivariable-adjusted Cox proportional hazards models (adjusted for age, sex, smoke, previous coronary arterial disease, blood pressure, and medications for hyperlipidemia, hyperuricemia and renin–angiotensin system inhibitors). Results Overall, 40.5% of participants had DM and 66.4% had hyperuricemia. In total, 356 deaths and 932 ESKD events occurred during the 7 years follow-up. With the multivariate analysis, increased risks for all-cause mortality were: hyperuricemia alone, HR = 1.48 (1–2.19); DM alone, and HR = 1.52 (1.02–2.46); DM and hyperuricemia together, HR = 2.12 (1.41–3.19). Similar risks for ESKD were: hyperuricemia alone, HR = 1.34 (1.03–1.73); DM alone, HR = 1.59 (1.15–2.2); DM and hyperuricemia together, HR = 2.46 (1.87–3.22). Conclusions DM and hyperuricemia are strongly associated with higher all-cause mortality and ESKD risk in patients with CKD stage 3–5. Hyperuricemia is similar to DM in terms of risk for all-cause mortality and ESKD. DM and hyperuricemia when occurred together further increase both risks of all-cause mortality and ESKD. |
| first_indexed | 2024-12-10T13:34:58Z |
| format | Article |
| id | doaj.art-a34a0a505cf64c5fb97a705998f2a0c7 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-10T13:34:58Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-a34a0a505cf64c5fb97a705998f2a0c72022-12-22T01:46:51ZengBMCBMC Nephrology1471-23692022-04-0123111010.1186/s12882-022-02755-1Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney diseaseCheng-Hung Li0Chia-Lin Lee1Yu-Cheng Hsieh2Cheng-Hsu Chen3Ming-Ju Wu4Shang-Feng Tsai5Department of cardiovascular disease, Taichung Veterans General HospitalDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of cardiovascular disease, Taichung Veterans General HospitalDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversityDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversitySchool of Medicine, National Yang-Ming UniversityAbstract Introduction Hyperuricemia and diabetes mellitus (DM) are associated with increased mortality risk in patients with chronic kidney disease (CKD). Here we aimed to evaluate the independent and joint risks of these two conditions on mortality and end stage kidney disease (ESKD) in CKD-patients. Methods This retrospective cohort study enrolled 4380 outpatients (with CKD stage 3–5) with mortality and ESKD linkage during a 7-year period (from 2007 to 2013). All-causes mortality and ESKD risks were analyzed by multivariable-adjusted Cox proportional hazards models (adjusted for age, sex, smoke, previous coronary arterial disease, blood pressure, and medications for hyperlipidemia, hyperuricemia and renin–angiotensin system inhibitors). Results Overall, 40.5% of participants had DM and 66.4% had hyperuricemia. In total, 356 deaths and 932 ESKD events occurred during the 7 years follow-up. With the multivariate analysis, increased risks for all-cause mortality were: hyperuricemia alone, HR = 1.48 (1–2.19); DM alone, and HR = 1.52 (1.02–2.46); DM and hyperuricemia together, HR = 2.12 (1.41–3.19). Similar risks for ESKD were: hyperuricemia alone, HR = 1.34 (1.03–1.73); DM alone, HR = 1.59 (1.15–2.2); DM and hyperuricemia together, HR = 2.46 (1.87–3.22). Conclusions DM and hyperuricemia are strongly associated with higher all-cause mortality and ESKD risk in patients with CKD stage 3–5. Hyperuricemia is similar to DM in terms of risk for all-cause mortality and ESKD. DM and hyperuricemia when occurred together further increase both risks of all-cause mortality and ESKD.https://doi.org/10.1186/s12882-022-02755-1HyperuricemiaDiabetes mellitusdialysisMortalityChronic kidney disease |
| spellingShingle | Cheng-Hung Li Chia-Lin Lee Yu-Cheng Hsieh Cheng-Hsu Chen Ming-Ju Wu Shang-Feng Tsai Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease BMC Nephrology Hyperuricemia Diabetes mellitus dialysis Mortality Chronic kidney disease |
| title | Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease |
| title_full | Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease |
| title_fullStr | Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease |
| title_full_unstemmed | Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease |
| title_short | Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease |
| title_sort | hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all cause mortality and end stage renal disease in patients with chronic kidney disease |
| topic | Hyperuricemia Diabetes mellitus dialysis Mortality Chronic kidney disease |
| url | https://doi.org/10.1186/s12882-022-02755-1 |
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