Zuo-Gui-Wan Aqueous Extract Ameliorates Glucocorticoid-Induced Spinal Osteoporosis of Rats by Regulating let-7f and Autophagy

Zuo-Gui-Wan Aqueous Extract Ameliorates Glucocorticoid-Induced Spinal Osteoporosis of Rats by Regulating let-7f and Autophagy

ObjectiveThis study proposes to explore the protective effect of Zuo-Gui-Wan (ZGW) aqueous extract on spinal glucocorticoid-induced osteoporosis (GIOP) in vivo and in vitro, and the underlying mechanisms of ZGW in GIOP and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMS...

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Bibliographic Details
Main Authors: Gengyang Shen, Qi Shang, Zhida Zhang, Wenhua Zhao, Honglin Chen, Ibrayinjan Mijiti, Guifeng Chen, Xiang Yu, Fuyong Yu, Peng Zhang, Jiahui He, Xuelai Zhang, Jingjing Tang, Jianchao Cui, De Liang, Lingfeng Zeng, Hui Ren, Xiaobing Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Endocrinology
Subjects:
ZGW aqueous extract
GIOP
let-7f
autophagy
Chinese medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.878963/full

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