The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro

The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro

PPAPs (Polycyclic polyprenylated acylphloroglucinols) are a class of compounds with diverse bioactivities, including anticancer effects. Oblongifolin C (OC) is a PPAP isolated from the plant of Garcinia yunnanensis Hu. We previously discovered that OC induces apoptosis, inhibits autophagic flux, and...

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Bibliographic Details
Main Authors: Li Han, Danqing Xu, Zhichao Xi, Man Wu, Wan Najbah Nik Nabil, Juan Zhang, Hua Sui, Wenwei Fu, Hua Zhou, Yuanzhi Lao, Gang Xu, Cheng Guo, Hongxi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
natural compounds
oblongifolin C
HSPA8
cathepsin B
protein fishing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.564833/full

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