Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i>
Colistin is an important last-line antibiotic to treat highly resistant <i>Enterobacter</i> infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical <i>Enterobacter</i> isolat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/11/825 |
| Summary: | Colistin is an important last-line antibiotic to treat highly resistant <i>Enterobacter</i> infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical <i>Enterobacter</i> isolate with a deletion of <i>mgrB</i>, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in <i>Enterobacter</i>. |
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| ISSN: | 2079-6382 |