Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i>
Colistin is an important last-line antibiotic to treat highly resistant <i>Enterobacter</i> infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical <i>Enterobacter</i> isolat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/11/825 |
| _version_ | 1797547504180396032 |
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| author | Jessie E. Wozniak Aroon T. Chande Eileen M. Burd Victor I. Band Sarah W. Satola Monica M. Farley Jesse T. Jacob I. King Jordan David S. Weiss |
| author_facet | Jessie E. Wozniak Aroon T. Chande Eileen M. Burd Victor I. Band Sarah W. Satola Monica M. Farley Jesse T. Jacob I. King Jordan David S. Weiss |
| author_sort | Jessie E. Wozniak |
| collection | DOAJ |
| description | Colistin is an important last-line antibiotic to treat highly resistant <i>Enterobacter</i> infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical <i>Enterobacter</i> isolate with a deletion of <i>mgrB</i>, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in <i>Enterobacter</i>. |
| first_indexed | 2024-03-10T14:45:01Z |
| format | Article |
| id | doaj.art-a34bf5c1ff7c45d58a71aab9a8d9b930 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T14:45:01Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-a34bf5c1ff7c45d58a71aab9a8d9b9302023-11-20T21:28:39ZengMDPI AGAntibiotics2079-63822020-11-0191182510.3390/antibiotics9110825Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i>Jessie E. Wozniak0Aroon T. Chande1Eileen M. Burd2Victor I. Band3Sarah W. Satola4Monica M. Farley5Jesse T. Jacob6I. King Jordan7David S. Weiss8Emory Vaccine Center, Atlanta, GA 30317, USAInstitute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USASchool of Medicine, Emory University, Atlanta, GA 30322, USAEmory Vaccine Center, Atlanta, GA 30317, USASchool of Medicine, Emory University, Atlanta, GA 30322, USASchool of Medicine, Emory University, Atlanta, GA 30322, USASchool of Medicine, Emory University, Atlanta, GA 30322, USASchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USAEmory Vaccine Center, Atlanta, GA 30317, USAColistin is an important last-line antibiotic to treat highly resistant <i>Enterobacter</i> infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical <i>Enterobacter</i> isolate with a deletion of <i>mgrB</i>, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in <i>Enterobacter</i>.https://www.mdpi.com/2079-6382/9/11/825colistin<i>Enterobacter</i>CRE |
| spellingShingle | Jessie E. Wozniak Aroon T. Chande Eileen M. Burd Victor I. Band Sarah W. Satola Monica M. Farley Jesse T. Jacob I. King Jordan David S. Weiss Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i> Antibiotics colistin <i>Enterobacter</i> CRE |
| title | Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i> |
| title_full | Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i> |
| title_fullStr | Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i> |
| title_full_unstemmed | Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i> |
| title_short | Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i> |
| title_sort | absence of i mgrb i alleviates negative growth effects of colistin resistance in i enterobacter cloacae i |
| topic | colistin <i>Enterobacter</i> CRE |
| url | https://www.mdpi.com/2079-6382/9/11/825 |
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