Genetic and molecular biology of autism spectrum disorder among Middle East population: a review
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disease, characterized by impaired social communication, executive dysfunction, and abnormal perceptual processing. It is more frequent among males. All of these clinical manifestations are associated with atypical neural dev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40246-021-00319-2 |
| _version_ | 1811306441424764928 |
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| author | Zahra Rahmani Mohammad Reza Fayyazi Bordbar Mohsen Dibaj Maliheh Alimardani Meysam Moghbeli |
| author_facet | Zahra Rahmani Mohammad Reza Fayyazi Bordbar Mohsen Dibaj Maliheh Alimardani Meysam Moghbeli |
| author_sort | Zahra Rahmani |
| collection | DOAJ |
| description | Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disease, characterized by impaired social communication, executive dysfunction, and abnormal perceptual processing. It is more frequent among males. All of these clinical manifestations are associated with atypical neural development. Various genetic and environmental risk factors are involved in the etiology of autism. Genetic assessment is essential for the early detection and intervention which can improve social communications and reduce abnormal behaviors. Although, there is a noticeable ASD incidence in Middle East countries, there is still a lack of knowledge about the genetic and molecular biology of ASD among this population to introduce efficient diagnostic and prognostic methods. Main body In the present review, we have summarized all of the genes which have been associated with ASD progression among Middle East population. We have also categorized the reported genes based on their cell and molecular functions. Conclusions This review clarifies the genetic and molecular biology of ASD among Middle East population and paves the way of introducing an efficient population based panel of genetic markers for the early detection and management of ASD in Middle East countries. |
| first_indexed | 2024-04-13T08:44:27Z |
| format | Article |
| id | doaj.art-a34d8a77bca14c9ba0337573dc00cf83 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-13T08:44:27Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-a34d8a77bca14c9ba0337573dc00cf832022-12-22T02:53:44ZengBMCHuman Genomics1479-73642021-03-0115111210.1186/s40246-021-00319-2Genetic and molecular biology of autism spectrum disorder among Middle East population: a reviewZahra Rahmani0Mohammad Reza Fayyazi Bordbar1Mohsen Dibaj2Maliheh Alimardani3Meysam Moghbeli4Department of Medical Genetics, Golestan University of Medical SciencesPsychiatry and Behavioral Sciences Research Center, Mashhad University of Medical SciencesDepartment of Biological Sciences, School of Natural Sciences, University of TabrizDepartment of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical SciencesDepartment of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical SciencesAbstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disease, characterized by impaired social communication, executive dysfunction, and abnormal perceptual processing. It is more frequent among males. All of these clinical manifestations are associated with atypical neural development. Various genetic and environmental risk factors are involved in the etiology of autism. Genetic assessment is essential for the early detection and intervention which can improve social communications and reduce abnormal behaviors. Although, there is a noticeable ASD incidence in Middle East countries, there is still a lack of knowledge about the genetic and molecular biology of ASD among this population to introduce efficient diagnostic and prognostic methods. Main body In the present review, we have summarized all of the genes which have been associated with ASD progression among Middle East population. We have also categorized the reported genes based on their cell and molecular functions. Conclusions This review clarifies the genetic and molecular biology of ASD among Middle East population and paves the way of introducing an efficient population based panel of genetic markers for the early detection and management of ASD in Middle East countries.https://doi.org/10.1186/s40246-021-00319-2AutismGeneticRisk factorDiagnosisPrognosisMiddle East |
| spellingShingle | Zahra Rahmani Mohammad Reza Fayyazi Bordbar Mohsen Dibaj Maliheh Alimardani Meysam Moghbeli Genetic and molecular biology of autism spectrum disorder among Middle East population: a review Human Genomics Autism Genetic Risk factor Diagnosis Prognosis Middle East |
| title | Genetic and molecular biology of autism spectrum disorder among Middle East population: a review |
| title_full | Genetic and molecular biology of autism spectrum disorder among Middle East population: a review |
| title_fullStr | Genetic and molecular biology of autism spectrum disorder among Middle East population: a review |
| title_full_unstemmed | Genetic and molecular biology of autism spectrum disorder among Middle East population: a review |
| title_short | Genetic and molecular biology of autism spectrum disorder among Middle East population: a review |
| title_sort | genetic and molecular biology of autism spectrum disorder among middle east population a review |
| topic | Autism Genetic Risk factor Diagnosis Prognosis Middle East |
| url | https://doi.org/10.1186/s40246-021-00319-2 |
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