Multifaceted Clinical Effects of Echinochrome
The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/8/412 |
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| author | Hyoung Kyu Kim Elena A. Vasileva Natalia P. Mishchenko Sergey A. Fedoreyev Jin Han |
| author_facet | Hyoung Kyu Kim Elena A. Vasileva Natalia P. Mishchenko Sergey A. Fedoreyev Jin Han |
| author_sort | Hyoung Kyu Kim |
| collection | DOAJ |
| description | The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases. |
| first_indexed | 2024-03-10T08:39:19Z |
| format | Article |
| id | doaj.art-a34f364d695945749deefc2ba8d7fd1e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T08:39:19Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a34f364d695945749deefc2ba8d7fd1e2023-11-22T08:25:17ZengMDPI AGMarine Drugs1660-33972021-07-0119841210.3390/md19080412Multifaceted Clinical Effects of EchinochromeHyoung Kyu Kim0Elena A. Vasileva1Natalia P. Mishchenko2Sergey A. Fedoreyev3Jin Han4Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Department of Physiology, College of Medicine, Inje University, Busan 57392, KoreaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, 690022 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, 690022 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, 690022 Vladivostok, RussiaCardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Department of Physiology, College of Medicine, Inje University, Busan 57392, KoreaThe marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases.https://www.mdpi.com/1660-3397/19/8/412histochromeechinochromeclinical effect |
| spellingShingle | Hyoung Kyu Kim Elena A. Vasileva Natalia P. Mishchenko Sergey A. Fedoreyev Jin Han Multifaceted Clinical Effects of Echinochrome Marine Drugs histochrome echinochrome clinical effect |
| title | Multifaceted Clinical Effects of Echinochrome |
| title_full | Multifaceted Clinical Effects of Echinochrome |
| title_fullStr | Multifaceted Clinical Effects of Echinochrome |
| title_full_unstemmed | Multifaceted Clinical Effects of Echinochrome |
| title_short | Multifaceted Clinical Effects of Echinochrome |
| title_sort | multifaceted clinical effects of echinochrome |
| topic | histochrome echinochrome clinical effect |
| url | https://www.mdpi.com/1660-3397/19/8/412 |
| work_keys_str_mv | AT hyoungkyukim multifacetedclinicaleffectsofechinochrome AT elenaavasileva multifacetedclinicaleffectsofechinochrome AT nataliapmishchenko multifacetedclinicaleffectsofechinochrome AT sergeyafedoreyev multifacetedclinicaleffectsofechinochrome AT jinhan multifacetedclinicaleffectsofechinochrome |