Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case
Primary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported in < 1% of all thyroid cancer cases. Primary SCC in the thyroid was thought to be a transitional form derived from adenocarcinomas; therefore, the majority of reported cases have focused on the conj...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-06-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/490410 |
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| author | Satoshi Koyama Kazunori Fujiwara Kanae Nosaka Takahiro Fukuhara Tsuyoshi Morisaki Naritomo Miyake Hiroya Kitano Hiromi Takeuchi |
| author_facet | Satoshi Koyama Kazunori Fujiwara Kanae Nosaka Takahiro Fukuhara Tsuyoshi Morisaki Naritomo Miyake Hiroya Kitano Hiromi Takeuchi |
| author_sort | Satoshi Koyama |
| collection | DOAJ |
| description | Primary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported in < 1% of all thyroid cancer cases. Primary SCC in the thyroid was thought to be a transitional form derived from adenocarcinomas; therefore, the majority of reported cases have focused on the conjunction with other histological adenocarcinomas. A 73-year-old male presented to our hospital with bilateral vocal fold palsy and an anterior neck mass. Ultrasound sonography revealed a bulky tumor in the thyroid and bilateral cervical lymphadenopathy. We performed fine-needle aspiration cytology from the thyroid tumor, which revealed SCC. Positron emission tomography/computed tomography showed distant metastases in the lungs, mediastinal lymph nodes, and vertebra. We diagnosed the patient as having stage IVC SCC in the thyroid and administered weekly paclitaxel. Four and a half months after treatment initiation, the tumor progression resulted in aspiration pneumonia, which proved fatal. We performed an autopsy in accordance with the patient’s wishes. Pathological findings revealed that all carcinomas in the thyroid, cervical lymph nodes, and lungs were pure SCCs. Immunohistochemical examinations for PAX8, thyroglobulin, and TTF-1 were all negative. Differentiated thyroid carcinomas have 3 major positive markers – PAX8, thyroglobulin, and TTF-1 –, and PAX8 is also sometimes positive for SCC in the thyroid. PAX8 positivity of SCC in the thyroid might, however, be associated with conjunction with other histological adenocarcinomas such as papillary or follicular thyroid carcinoma; therefore, pure SCC in the thyroid might be negative for PAX8. |
| first_indexed | 2024-04-12T01:55:03Z |
| format | Article |
| id | doaj.art-a351a56bfa024f7d8a83457be77871ff |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T01:55:03Z |
| publishDate | 2018-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-a351a56bfa024f7d8a83457be77871ff2022-12-22T03:52:50ZengKarger PublishersCase Reports in Oncology1662-65752018-06-0111241842410.1159/000490410490410Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy CaseSatoshi KoyamaKazunori FujiwaraKanae NosakaTakahiro FukuharaTsuyoshi MorisakiNaritomo MiyakeHiroya KitanoHiromi TakeuchiPrimary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported in < 1% of all thyroid cancer cases. Primary SCC in the thyroid was thought to be a transitional form derived from adenocarcinomas; therefore, the majority of reported cases have focused on the conjunction with other histological adenocarcinomas. A 73-year-old male presented to our hospital with bilateral vocal fold palsy and an anterior neck mass. Ultrasound sonography revealed a bulky tumor in the thyroid and bilateral cervical lymphadenopathy. We performed fine-needle aspiration cytology from the thyroid tumor, which revealed SCC. Positron emission tomography/computed tomography showed distant metastases in the lungs, mediastinal lymph nodes, and vertebra. We diagnosed the patient as having stage IVC SCC in the thyroid and administered weekly paclitaxel. Four and a half months after treatment initiation, the tumor progression resulted in aspiration pneumonia, which proved fatal. We performed an autopsy in accordance with the patient’s wishes. Pathological findings revealed that all carcinomas in the thyroid, cervical lymph nodes, and lungs were pure SCCs. Immunohistochemical examinations for PAX8, thyroglobulin, and TTF-1 were all negative. Differentiated thyroid carcinomas have 3 major positive markers – PAX8, thyroglobulin, and TTF-1 –, and PAX8 is also sometimes positive for SCC in the thyroid. PAX8 positivity of SCC in the thyroid might, however, be associated with conjunction with other histological adenocarcinomas such as papillary or follicular thyroid carcinoma; therefore, pure SCC in the thyroid might be negative for PAX8.https://www.karger.com/Article/FullText/490410AutopsyPaired box 8PAX8Squamous cell carcinomaThyroid |
| spellingShingle | Satoshi Koyama Kazunori Fujiwara Kanae Nosaka Takahiro Fukuhara Tsuyoshi Morisaki Naritomo Miyake Hiroya Kitano Hiromi Takeuchi Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case Case Reports in Oncology Autopsy Paired box 8 PAX8 Squamous cell carcinoma Thyroid |
| title | Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case |
| title_full | Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case |
| title_fullStr | Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case |
| title_full_unstemmed | Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case |
| title_short | Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case |
| title_sort | immunohistochemical features of primary pure squamous cell carcinoma in the thyroid an autopsy case |
| topic | Autopsy Paired box 8 PAX8 Squamous cell carcinoma Thyroid |
| url | https://www.karger.com/Article/FullText/490410 |
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