Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review
Background The novel coronavirus disease-2019 (COVID-19), which is caused by Severe Acute Respiratory Distress Syndrome coronavirus 2 (SARS-CoV2), was originally detected in Wuhan, China in December 2019. In this meta-analysis and literature review, we compared and summarized the clinical presenta...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2023-05-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/43563 |
| _version_ | 1797832919189815296 |
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| author | Nikola Siekierko Maja Żołnierek Wiktoria Kotusiewicz Mateusz Lewandowski Grzegorz Bienia Zuzanna Lubczyńska Yevheniia Popravko Jakub Świętochowski |
| author_facet | Nikola Siekierko Maja Żołnierek Wiktoria Kotusiewicz Mateusz Lewandowski Grzegorz Bienia Zuzanna Lubczyńska Yevheniia Popravko Jakub Świętochowski |
| author_sort | Nikola Siekierko |
| collection | DOAJ |
| description | Background
The novel coronavirus disease-2019 (COVID-19), which is caused by Severe Acute Respiratory Distress Syndrome coronavirus 2 (SARS-CoV2), was originally detected in Wuhan, China in December 2019. In this meta-analysis and literature review, we compared and summarized the clinical presentation, cerebrospinal fluid (CSF) and electromyography (EMG) findings and outcomes in SARS-CoV-2 patients with Guillain-Barre Syndrome (GBS) and its variants.
Methods
We conducted a literature review in February 2023 searching for terms “Guillain-Barre Syndrome and COVID-19", “SARS neurology”, “COVID-19 complications”. We used PubMed and Google Scholar databases inquiring case reports or series of cases published between April 1, 2020, and September 14, 2023.
Results
Of the 52 GBS cases 61,5% (n=32) were male and 39,5% (n=20) were female. The mean age was 57 years old. A total of 75% (n=33) patients presented acute inflammatory demyelinating polyneuropathy (AIDP) variant, 6,8% (n=3) presented acute motor axonal neuropathy (AMAN) variant, 15,9% (n=7) presented acute motor-sensory axonal neuropathy (AMSAN) variant. A total of 85,7% (n=42) of patients were diagnosed with albuminocytological dissociation. During the hospitalization, a total of 30,8% (n=16) required mechanical ventilation. A total of 61,5% (n=32) of patients were treated with a 5-day regimen of intravenous immunoglobulin (IVIG) in dose 0.4 g/kg/day. There were 46,1% (n=24) complete recoveries from GBS, 32,7% (n=17) partial recoveries and 9,6% (n=5) of patients did not respond to treatment. A total of 11,5% (n=6) of patients died.
Conclusion
It is crucial to follow patients with COVID-19 and GBS over time to estimate properly the efficacy of treatment and evaluate the real percentage of recovery and complications.
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| first_indexed | 2024-04-09T14:15:27Z |
| format | Article |
| id | doaj.art-a35201bca5c34b71890d4eb00d1ec736 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-09T14:15:27Z |
| publishDate | 2023-05-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-a35201bca5c34b71890d4eb00d1ec7362023-05-05T10:45:48ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062023-05-0125110.12775/JEHS.2023.25.01.004Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature reviewNikola Siekierko0Maja Żołnierek1Wiktoria Kotusiewicz2Mateusz Lewandowski3Grzegorz Bienia4Zuzanna Lubczyńska5Yevheniia Popravko6Jakub Świętochowski7Szpital Praski pw. Przemienienia PańskiegoSamodzielny Publiczny Specjalistyczny Szpital Zachodni im. św. Jana Pawła IIWojskowy Instytut Medyczny- Państwowy Instytut BadawczyUNIVERSITY CLINICAL CENTER OF WARSAW MEDICAL UNIVERSITYMilitary Institute of Medicine-National Research InstituteSzpital Grochowski im. dr med. Rafała MasztakaSzpital Praski pw. Przemienienia PańskiegoUniwersyteckie Centrum Kliniczne w GdańskuBackground The novel coronavirus disease-2019 (COVID-19), which is caused by Severe Acute Respiratory Distress Syndrome coronavirus 2 (SARS-CoV2), was originally detected in Wuhan, China in December 2019. In this meta-analysis and literature review, we compared and summarized the clinical presentation, cerebrospinal fluid (CSF) and electromyography (EMG) findings and outcomes in SARS-CoV-2 patients with Guillain-Barre Syndrome (GBS) and its variants. Methods We conducted a literature review in February 2023 searching for terms “Guillain-Barre Syndrome and COVID-19", “SARS neurology”, “COVID-19 complications”. We used PubMed and Google Scholar databases inquiring case reports or series of cases published between April 1, 2020, and September 14, 2023. Results Of the 52 GBS cases 61,5% (n=32) were male and 39,5% (n=20) were female. The mean age was 57 years old. A total of 75% (n=33) patients presented acute inflammatory demyelinating polyneuropathy (AIDP) variant, 6,8% (n=3) presented acute motor axonal neuropathy (AMAN) variant, 15,9% (n=7) presented acute motor-sensory axonal neuropathy (AMSAN) variant. A total of 85,7% (n=42) of patients were diagnosed with albuminocytological dissociation. During the hospitalization, a total of 30,8% (n=16) required mechanical ventilation. A total of 61,5% (n=32) of patients were treated with a 5-day regimen of intravenous immunoglobulin (IVIG) in dose 0.4 g/kg/day. There were 46,1% (n=24) complete recoveries from GBS, 32,7% (n=17) partial recoveries and 9,6% (n=5) of patients did not respond to treatment. A total of 11,5% (n=6) of patients died. Conclusion It is crucial to follow patients with COVID-19 and GBS over time to estimate properly the efficacy of treatment and evaluate the real percentage of recovery and complications. https://apcz.umk.pl/JEHS/article/view/43563AIDPAMSANCOVID-19GBSSARS-CoV-2 |
| spellingShingle | Nikola Siekierko Maja Żołnierek Wiktoria Kotusiewicz Mateusz Lewandowski Grzegorz Bienia Zuzanna Lubczyńska Yevheniia Popravko Jakub Świętochowski Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review Journal of Education, Health and Sport AIDP AMSAN COVID-19 GBS SARS-CoV-2 |
| title | Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review |
| title_full | Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review |
| title_fullStr | Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review |
| title_full_unstemmed | Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review |
| title_short | Guillain-Barre Syndrome linked to SARS-CoV-2 infection – meta-analysis and literature review |
| title_sort | guillain barre syndrome linked to sars cov 2 infection meta analysis and literature review |
| topic | AIDP AMSAN COVID-19 GBS SARS-CoV-2 |
| url | https://apcz.umk.pl/JEHS/article/view/43563 |
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