Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma
Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1063423/full |
| _version_ | 1797959826363383808 |
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| author | Yiwei Xu Xiaodong Hao Yidan Ren Qinchen Xu Xiaoyan Liu Shuliang Song Yunshan Wang |
| author_facet | Yiwei Xu Xiaodong Hao Yidan Ren Qinchen Xu Xiaoyan Liu Shuliang Song Yunshan Wang |
| author_sort | Yiwei Xu |
| collection | DOAJ |
| description | Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the “Warburg effect” in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma. |
| first_indexed | 2024-04-11T00:37:11Z |
| format | Article |
| id | doaj.art-a3525c014b09442eadb9d16b7cad4d1f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T00:37:11Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a3525c014b09442eadb9d16b7cad4d1f2023-01-06T15:35:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10634231063423Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinomaYiwei Xu0Xiaodong Hao1Yidan Ren2Qinchen Xu3Xiaoyan Liu4Shuliang Song5Yunshan Wang6Marine College, Shandong University, Weihai, ChinaDepartment of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaMarine College, Shandong University, Weihai, ChinaDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaTumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the “Warburg effect” in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma.https://www.frontiersin.org/articles/10.3389/fonc.2022.1063423/fulllactate metabolismlactylationimmune regulationimmunotherapyhepatocellular carcinoma |
| spellingShingle | Yiwei Xu Xiaodong Hao Yidan Ren Qinchen Xu Xiaoyan Liu Shuliang Song Yunshan Wang Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma Frontiers in Oncology lactate metabolism lactylation immune regulation immunotherapy hepatocellular carcinoma |
| title | Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma |
| title_full | Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma |
| title_fullStr | Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma |
| title_full_unstemmed | Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma |
| title_short | Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma |
| title_sort | research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma |
| topic | lactate metabolism lactylation immune regulation immunotherapy hepatocellular carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1063423/full |
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