Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles
A new library of various types of aryl pyrimidine-thiadiazoles (8a-j) have been synthesized and their structures characterized by analytical techniques. Further, all compounds were subjected to in vitro anticancer activity towards four human cancer cell lines such as PC3 & DU-145 (Prostate c...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624001462 |
| _version_ | 1797220281716047872 |
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| author | Veera Reddy Yenireddy Kandukuri Usha Rani Anuradha Vejendla |
| author_facet | Veera Reddy Yenireddy Kandukuri Usha Rani Anuradha Vejendla |
| author_sort | Veera Reddy Yenireddy |
| collection | DOAJ |
| description | A new library of various types of aryl pyrimidine-thiadiazoles (8a-j) have been synthesized and their structures characterized by analytical techniques. Further, all compounds were subjected to in vitro anticancer activity towards four human cancer cell lines such as PC3 & DU-145 (Prostate cancer), A459 (lung cancer) and MCF-7 (breast cancer) by using MTT assay and etoposide used as reference compound. Most of the tested compounds displayed excellent to moderate activity. Among them, compounds 8a, 8d, 8e, 8f and 8g showed more potent activity. In which one compound 8e showed remarkable activity. |
| first_indexed | 2024-04-24T12:47:03Z |
| format | Article |
| id | doaj.art-a352a44acc164ee7956b526cf7046014 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-24T12:47:03Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-a352a44acc164ee7956b526cf70460142024-04-07T04:35:37ZengElsevierResults in Chemistry2211-71562024-01-017101450Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazolesVeera Reddy Yenireddy0Kandukuri Usha Rani1Anuradha Vejendla2Department of Chemistry, Vignan’s Foundation for Science Technology and Research, University (VFSTR), Vadlamudi, Guntur 522213, IndiaDepartment of Chemistry,Indira Priyadarshini Governament Degree College For Womem, Nampally, Hyderabad, Telangana 500001, IndiaDepartment of BSH, Vignan‘s NIRULA Institute of Technology and Science, Pedapalakaluru Road Guntur, 522005, India; Corresponding author.A new library of various types of aryl pyrimidine-thiadiazoles (8a-j) have been synthesized and their structures characterized by analytical techniques. Further, all compounds were subjected to in vitro anticancer activity towards four human cancer cell lines such as PC3 & DU-145 (Prostate cancer), A459 (lung cancer) and MCF-7 (breast cancer) by using MTT assay and etoposide used as reference compound. Most of the tested compounds displayed excellent to moderate activity. Among them, compounds 8a, 8d, 8e, 8f and 8g showed more potent activity. In which one compound 8e showed remarkable activity.http://www.sciencedirect.com/science/article/pii/S2211715624001462InfigratinibPyrimidineAzetepa1,3,4-thiadiazole and anticancer activity |
| spellingShingle | Veera Reddy Yenireddy Kandukuri Usha Rani Anuradha Vejendla Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles Results in Chemistry Infigratinib Pyrimidine Azetepa 1,3,4-thiadiazole and anticancer activity |
| title | Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles |
| title_full | Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles |
| title_fullStr | Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles |
| title_full_unstemmed | Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles |
| title_short | Design, synthesis and anticancer evaluation of aryl pyrimidine-thiadiazoles |
| title_sort | design synthesis and anticancer evaluation of aryl pyrimidine thiadiazoles |
| topic | Infigratinib Pyrimidine Azetepa 1,3,4-thiadiazole and anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624001462 |
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