A real-world study on the changing characteristics of measles antibodies in premature infants in China
ABSTRACTThe waning of maternal antibodies may cause infants to lose protection against measles before receiving measles-containing vaccine (MCV). The aim of this study is to investigate the changing characteristics and influencing factors of measles antibodies in preterm infants (PT), and to provide...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2338505 |
| _version_ | 1797215106039283712 |
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| author | Mingyan Li Weiwei Zhang Shuangshuang Zheng Junxia Guo Hanqing He Yongjun Ma Yan Huang Yan Feng Chai Ji |
| author_facet | Mingyan Li Weiwei Zhang Shuangshuang Zheng Junxia Guo Hanqing He Yongjun Ma Yan Huang Yan Feng Chai Ji |
| author_sort | Mingyan Li |
| collection | DOAJ |
| description | ABSTRACTThe waning of maternal antibodies may cause infants to lose protection against measles before receiving measles-containing vaccine (MCV). The aim of this study is to investigate the changing characteristics and influencing factors of measles antibodies in preterm infants (PT), and to provide scientific basis for optimizing MCV vaccination strategy of the target population. Blood samples were collected from PT and full-term infants (FT) at the chronological age (CA) of 3, 6, and 12 months. Measles antibodies were quantitatively detected by enzyme-linked immunosorbent assay. Demographic and vaccination information were both collected. Kruskal–Wallis rank sum test was used to compare the measles antibodies among different gestation age (GA) groups, and multiple linear regression was performed to identify the correlative factors for the antibodies. Measles antibodies of PT decreased significantly with age increasing before MCV vaccination. The positive rates of antibodies of PT were 10.80% and 3.30% at the age of 3 and 6 months, respectively (p < .001). At 12 months, the measles antibodies and seropositive rate in the infants who received MCV vaccination increased sharply (p < .001). Regression analyzes showed that the younger the GA or the older the age, the lower the antibodies at 3 months(p < .001，p = .018); while the lower measles antibody levels at 3 months and older age predicted the lower antibodies at 6 months(p < .001, p = .029). PT were susceptible to measles due to the low level of maternally derived antibodies before MCV vaccination. More efforts should be considered to protect the vulnerable population during their early postnatal life. |
| first_indexed | 2024-04-24T11:24:47Z |
| format | Article |
| id | doaj.art-a352e49b764543d6a766b4e7c088b0ee |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-04-24T11:24:47Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-a352e49b764543d6a766b4e7c088b0ee2024-04-11T01:01:11ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2338505A real-world study on the changing characteristics of measles antibodies in premature infants in ChinaMingyan Li0Weiwei Zhang1Shuangshuang Zheng2Junxia Guo3Hanqing He4Yongjun Ma5Yan Huang6Yan Feng7Chai Ji8Department of Child Health Care, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Child Health Care, Maternal and Child Health Hospital of Changxing, Huzhou, ChinaDepartment of Child Health Care, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Child Health Care, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Pediatrics, Maternal and Child Healthcare Hospital Department of Shangyu, Shaoxing, ChinaDepartment of Immunization Program, Center for Disease Control and Prevention of Shangyu, Shaoxing, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Child Health Care, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaABSTRACTThe waning of maternal antibodies may cause infants to lose protection against measles before receiving measles-containing vaccine (MCV). The aim of this study is to investigate the changing characteristics and influencing factors of measles antibodies in preterm infants (PT), and to provide scientific basis for optimizing MCV vaccination strategy of the target population. Blood samples were collected from PT and full-term infants (FT) at the chronological age (CA) of 3, 6, and 12 months. Measles antibodies were quantitatively detected by enzyme-linked immunosorbent assay. Demographic and vaccination information were both collected. Kruskal–Wallis rank sum test was used to compare the measles antibodies among different gestation age (GA) groups, and multiple linear regression was performed to identify the correlative factors for the antibodies. Measles antibodies of PT decreased significantly with age increasing before MCV vaccination. The positive rates of antibodies of PT were 10.80% and 3.30% at the age of 3 and 6 months, respectively (p < .001). At 12 months, the measles antibodies and seropositive rate in the infants who received MCV vaccination increased sharply (p < .001). Regression analyzes showed that the younger the GA or the older the age, the lower the antibodies at 3 months(p < .001，p = .018); while the lower measles antibody levels at 3 months and older age predicted the lower antibodies at 6 months(p < .001, p = .029). PT were susceptible to measles due to the low level of maternally derived antibodies before MCV vaccination. More efforts should be considered to protect the vulnerable population during their early postnatal life.https://www.tandfonline.com/doi/10.1080/21645515.2024.2338505Measlesmeasles antibodypreterm infantscorrelative factorsmeasles-containing vaccine |
| spellingShingle | Mingyan Li Weiwei Zhang Shuangshuang Zheng Junxia Guo Hanqing He Yongjun Ma Yan Huang Yan Feng Chai Ji A real-world study on the changing characteristics of measles antibodies in premature infants in China Human Vaccines & Immunotherapeutics Measles measles antibody preterm infants correlative factors measles-containing vaccine |
| title | A real-world study on the changing characteristics of measles antibodies in premature infants in China |
| title_full | A real-world study on the changing characteristics of measles antibodies in premature infants in China |
| title_fullStr | A real-world study on the changing characteristics of measles antibodies in premature infants in China |
| title_full_unstemmed | A real-world study on the changing characteristics of measles antibodies in premature infants in China |
| title_short | A real-world study on the changing characteristics of measles antibodies in premature infants in China |
| title_sort | real world study on the changing characteristics of measles antibodies in premature infants in china |
| topic | Measles measles antibody preterm infants correlative factors measles-containing vaccine |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2338505 |
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