Structural insights into chaperone addiction of toxin-antitoxin systems
SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in c...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08747-4 |
| _version_ | 1818996703413403648 |
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| author | Valérie Guillet Patricia Bordes Cécile Bon Julien Marcoux Virginie Gervais Ambre Julie Sala Suzana Dos Reis Nawel Slama Israel Mares-Mejía Anne-Marie Cirinesi Laurent Maveyraud Pierre Genevaux Lionel Mourey |
| author_facet | Valérie Guillet Patricia Bordes Cécile Bon Julien Marcoux Virginie Gervais Ambre Julie Sala Suzana Dos Reis Nawel Slama Israel Mares-Mejía Anne-Marie Cirinesi Laurent Maveyraud Pierre Genevaux Lionel Mourey |
| author_sort | Valérie Guillet |
| collection | DOAJ |
| description | SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in complex with the C-terminal ChAD (chaperone addiction) extension of the antitoxin HigA1. |
| first_indexed | 2024-12-20T21:33:57Z |
| format | Article |
| id | doaj.art-a3545627c95b4aebbc2831156701c6af |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:33:57Z |
| publishDate | 2019-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a3545627c95b4aebbc2831156701c6af2022-12-21T19:25:59ZengNature PortfolioNature Communications2041-17232019-02-0110111510.1038/s41467-019-08747-4Structural insights into chaperone addiction of toxin-antitoxin systemsValérie Guillet0Patricia Bordes1Cécile Bon2Julien Marcoux3Virginie Gervais4Ambre Julie Sala5Suzana Dos Reis6Nawel Slama7Israel Mares-Mejía8Anne-Marie Cirinesi9Laurent Maveyraud10Pierre Genevaux11Lionel Mourey12Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSLaboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSLaboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSLaboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSLaboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSLaboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPSSecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in complex with the C-terminal ChAD (chaperone addiction) extension of the antitoxin HigA1.https://doi.org/10.1038/s41467-019-08747-4 |
| spellingShingle | Valérie Guillet Patricia Bordes Cécile Bon Julien Marcoux Virginie Gervais Ambre Julie Sala Suzana Dos Reis Nawel Slama Israel Mares-Mejía Anne-Marie Cirinesi Laurent Maveyraud Pierre Genevaux Lionel Mourey Structural insights into chaperone addiction of toxin-antitoxin systems Nature Communications |
| title | Structural insights into chaperone addiction of toxin-antitoxin systems |
| title_full | Structural insights into chaperone addiction of toxin-antitoxin systems |
| title_fullStr | Structural insights into chaperone addiction of toxin-antitoxin systems |
| title_full_unstemmed | Structural insights into chaperone addiction of toxin-antitoxin systems |
| title_short | Structural insights into chaperone addiction of toxin-antitoxin systems |
| title_sort | structural insights into chaperone addiction of toxin antitoxin systems |
| url | https://doi.org/10.1038/s41467-019-08747-4 |
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