Clinical and immunological characteristic of natural course at the early stages of HIV infection
An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection inc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2020-05-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1866 |
| _version_ | 1797197900718014464 |
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| author | E. R. Manapova V. Kh. Fazylov A. T. Beshimov |
| author_facet | E. R. Manapova V. Kh. Fazylov A. T. Beshimov |
| author_sort | E. R. Manapova |
| collection | DOAJ |
| description | An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients. |
| first_indexed | 2024-03-08T05:47:59Z |
| format | Article |
| id | doaj.art-a3546df037494b979efeb2553a83da25 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:51:19Z |
| publishDate | 2020-05-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a3546df037494b979efeb2553a83da252024-04-22T13:07:45ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2020-05-0122351952610.15789/1563-0625-CAI-18661286Clinical and immunological characteristic of natural course at the early stages of HIV infectionE. R. Manapova0V. Kh. Fazylov1A. T. Beshimov2Kazan State Medical UniversityKazan State Medical UniversityRepublican Center for the Prevention and Control of AIDS and Infectious DiseasesAn early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients.https://www.mimmun.ru/mimmun/article/view/1866hiv infectionhcv-infectionearly stageshcv/hiv-coinfectioncd4<sup>+</sup> lymphocytescd8<sup>+</sup> lymphocytes |
| spellingShingle | E. R. Manapova V. Kh. Fazylov A. T. Beshimov Clinical and immunological characteristic of natural course at the early stages of HIV infection Медицинская иммунология hiv infection hcv-infection early stages hcv/hiv-coinfection cd4<sup>+</sup> lymphocytes cd8<sup>+</sup> lymphocytes |
| title | Clinical and immunological characteristic of natural course at the early stages of HIV infection |
| title_full | Clinical and immunological characteristic of natural course at the early stages of HIV infection |
| title_fullStr | Clinical and immunological characteristic of natural course at the early stages of HIV infection |
| title_full_unstemmed | Clinical and immunological characteristic of natural course at the early stages of HIV infection |
| title_short | Clinical and immunological characteristic of natural course at the early stages of HIV infection |
| title_sort | clinical and immunological characteristic of natural course at the early stages of hiv infection |
| topic | hiv infection hcv-infection early stages hcv/hiv-coinfection cd4<sup>+</sup> lymphocytes cd8<sup>+</sup> lymphocytes |
| url | https://www.mimmun.ru/mimmun/article/view/1866 |
| work_keys_str_mv | AT ermanapova clinicalandimmunologicalcharacteristicofnaturalcourseattheearlystagesofhivinfection AT vkhfazylov clinicalandimmunologicalcharacteristicofnaturalcourseattheearlystagesofhivinfection AT atbeshimov clinicalandimmunologicalcharacteristicofnaturalcourseattheearlystagesofhivinfection |