Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain

Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain

Tuberous sclerosis complex (TSC) is an autosomal dominant neurogenetic disorder affecting the brain and other vital organs. Neurological symptoms include epilepsy, intellectual disability, and autism. TSC is caused by a loss-of-function mutation in the TSC1 or TSC2 gene. These gene products form a p...

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Bibliographic Details
Main Authors: Rebecca L. Cox, Froylan Calderon de Anda, Tomer Mangoubi, Akira Yoshii
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
tuberous sclerosis complex
neuronal migration
synapse formation
critical period
rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00409/full

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