PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development

PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development

Much of what is known about the mechanisms that control the developmental expression of the myelin proteolipid protein gene (PLP1) has been attained through use of transgenic animal models. In this study, we analyzed expression of related transgenes which utilize PLP1 genomic DNA from either human o...

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Bibliographic Details
Main Authors: Pankaj Patyal, Daniel Fil, Hamdan Hamdan, Patricia A. Wight
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
myelin proteolipid protein gene (PLP1)
splice variants
gene regulation
brain
RT-qPCR
transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1087145/full

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