The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis
The role of serotonin in the immediate and delayed influence of physical exercise on brain functions has been intensively studied in mammals. Recently, immediate effects of intense locomotion on the decision-making under uncertainty were reported in the Great Pond snail, Lymnaea stagnalis (Korshunov...
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00221/full |
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| author | Hitoshi Aonuma Hitoshi Aonuma Maxim Mezheritskiy Boris Boldyshev Yuki Totani Dmitry Vorontsov Igor Zakharov Etsuro Ito Varvara Dyakonova |
| author_facet | Hitoshi Aonuma Hitoshi Aonuma Maxim Mezheritskiy Boris Boldyshev Yuki Totani Dmitry Vorontsov Igor Zakharov Etsuro Ito Varvara Dyakonova |
| author_sort | Hitoshi Aonuma |
| collection | DOAJ |
| description | The role of serotonin in the immediate and delayed influence of physical exercise on brain functions has been intensively studied in mammals. Recently, immediate effects of intense locomotion on the decision-making under uncertainty were reported in the Great Pond snail, Lymnaea stagnalis (Korshunova et al., 2016). In this animal, serotonergic neurons control locomotion, and serotonin modulates many processes underlying behavior, including cognitive ones (memory and learning). Whether serotonin mediates the behavioral effects of intense locomotion in mollusks, as it does in vertebrates, remains unknown. Here, the delayed facilitating effects of intense locomotion on the decision-making in the novel environment are described in Lymnaea. Past exercise was found to alter the metabolism of serotonin, namely the content of serotonin precursor and its catabolites in the cerebral and pedal ganglia, as measured by high-performance liquid chromatography. The immediate and delayed effects of exercise on serotonin metabolism were different. Moreover, serotonin metabolism was regulated differently in different ganglia. Pharmacological manipulations of the serotonin content and receptor availability suggests that serotonin is likely to be responsible for the locomotor acceleration in the test of decision-making under uncertainty performed after exercise. However, the exercise-induced facilitation of decision-making (manifested in a reduced number of turns during the orienting behavior) cannot be attributed to the effects of serotonin. |
| first_indexed | 2024-12-20T05:04:51Z |
| format | Article |
| id | doaj.art-a3582850874940a3a83b8655e2101c34 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T05:04:51Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a3582850874940a3a83b8655e2101c342022-12-21T19:52:26ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-03-011110.3389/fphys.2020.00221468246The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalisHitoshi Aonuma0Hitoshi Aonuma1Maxim Mezheritskiy2Boris Boldyshev3Yuki Totani4Dmitry Vorontsov5Igor Zakharov6Etsuro Ito7Varvara Dyakonova8Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science, Hokkaido University, Hokkaido, JapanCore Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama, JapanKoltzov Institute of Developmental Biology of the Russian Academy of Sciences (RAS), Moscow, RussiaTrapeznikov Institute of Control Sciences of Russian Academy of Sciences (RAS), Moscow, RussiaDepartment of Biology, Waseda University, Tokyo, JapanKoltzov Institute of Developmental Biology of the Russian Academy of Sciences (RAS), Moscow, RussiaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences (RAS), Moscow, RussiaDepartment of Biology, Waseda University, Tokyo, JapanKoltzov Institute of Developmental Biology of the Russian Academy of Sciences (RAS), Moscow, RussiaThe role of serotonin in the immediate and delayed influence of physical exercise on brain functions has been intensively studied in mammals. Recently, immediate effects of intense locomotion on the decision-making under uncertainty were reported in the Great Pond snail, Lymnaea stagnalis (Korshunova et al., 2016). In this animal, serotonergic neurons control locomotion, and serotonin modulates many processes underlying behavior, including cognitive ones (memory and learning). Whether serotonin mediates the behavioral effects of intense locomotion in mollusks, as it does in vertebrates, remains unknown. Here, the delayed facilitating effects of intense locomotion on the decision-making in the novel environment are described in Lymnaea. Past exercise was found to alter the metabolism of serotonin, namely the content of serotonin precursor and its catabolites in the cerebral and pedal ganglia, as measured by high-performance liquid chromatography. The immediate and delayed effects of exercise on serotonin metabolism were different. Moreover, serotonin metabolism was regulated differently in different ganglia. Pharmacological manipulations of the serotonin content and receptor availability suggests that serotonin is likely to be responsible for the locomotor acceleration in the test of decision-making under uncertainty performed after exercise. However, the exercise-induced facilitation of decision-making (manifested in a reduced number of turns during the orienting behavior) cannot be attributed to the effects of serotonin.https://www.frontiersin.org/article/10.3389/fphys.2020.00221/fullserotonindecision-makingmolluskseffect of exercise on the braingoal-directed locomotion |
| spellingShingle | Hitoshi Aonuma Hitoshi Aonuma Maxim Mezheritskiy Boris Boldyshev Yuki Totani Dmitry Vorontsov Igor Zakharov Etsuro Ito Varvara Dyakonova The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis Frontiers in Physiology serotonin decision-making mollusks effect of exercise on the brain goal-directed locomotion |
| title | The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis |
| title_full | The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis |
| title_fullStr | The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis |
| title_full_unstemmed | The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis |
| title_short | The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis |
| title_sort | role of serotonin in the influence of intense locomotion on the behavior under uncertainty in the mollusk lymnaea stagnalis |
| topic | serotonin decision-making mollusks effect of exercise on the brain goal-directed locomotion |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00221/full |
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