Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study
Abstract Background and objectives Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incidence of ROP and evaluates potential risk factors associa...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | http://link.springer.com/article/10.1186/s40942-018-0125-z |
| _version_ | 1818406823993016320 |
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| author | André Moraes Freitas Ricardo Mörschbächer Mariana R. Thorell Ernani Luis Rhoden |
| author_facet | André Moraes Freitas Ricardo Mörschbächer Mariana R. Thorell Ernani Luis Rhoden |
| author_sort | André Moraes Freitas |
| collection | DOAJ |
| description | Abstract Background and objectives Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incidence of ROP and evaluates potential risk factors associated. Methods A retrospective cohort study of preterm infants born in a tertiary neonatal intensive care unit was conducted from March 2005 to August 2015. Six hundred and thirty-nine newborns were included based on the following criteria: infants born with less than 32 weeks’ gestation or birth weight below 1500 g; or neonates born with 32–37 weeks’ gestation or birth weight above 1500 g and any of the following associated: multiple gestation, respiratory distress syndrome, sepsis, blood transfusions or intraventricular hemorrhage. Neonates were followed up until disease resolution or until treatment criteria was achieved. Results A total of 602 newborns were evaluated after applying the exclusion criteria. Mean gestational age was 30.7 ± 2.5 weeks. The incidences of ROP at any stage and of type 1 prethreshold ROP were 33.9 and 5.0% respectively. Logistic regression analysis revealed that risk factors associated with ROP at any stage were extremely low birth weight (ELBW) (odds ratio [OR] = 3.10; 95% confidence interval [95% CI]:1.73–5.55), pulmonary diseases (OR = 2.49; 95% CI: 1.35–4.59), intraventricular hemorrhage (OR = 2.17; 95% CI: 1.10–4.30), and low gestational age (OR = 0.81; 95% CI: 0.73–0.91). The main risk factors associated with type 1 prethreshold ROP were pulmonary diseases (OR = 9.58; 95% CI: 1.27–72.04) and ELBW (OR = 3.66; 95% CI: 1.67–8.00). Conclusion This study found a significant incidence of ROP (33.9%) in the studied population, and highlighted pulmonary diseases as a significant risk factor for type 1 prethreshold ROP. |
| first_indexed | 2024-12-14T09:18:04Z |
| format | Article |
| id | doaj.art-a358b75803a6469a9ceff813ab32c31f |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-14T09:18:04Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-a358b75803a6469a9ceff813ab32c31f2022-12-21T23:08:22ZengBMCInternational Journal of Retina and Vitreous2056-99202018-05-01411810.1186/s40942-018-0125-zIncidence and risk factors for retinopathy of prematurity: a retrospective cohort studyAndré Moraes Freitas0Ricardo Mörschbächer1Mariana R. Thorell2Ernani Luis Rhoden3Universidade Federal de Ciências Da Saúde de Porto Alegre (UFCSPA)Universidade Federal de Ciências Da Saúde de Porto Alegre (UFCSPA)Royal Liverpool University HospitalUniversidade Federal de Ciências Da Saúde de Porto Alegre (UFCSPA)Abstract Background and objectives Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incidence of ROP and evaluates potential risk factors associated. Methods A retrospective cohort study of preterm infants born in a tertiary neonatal intensive care unit was conducted from March 2005 to August 2015. Six hundred and thirty-nine newborns were included based on the following criteria: infants born with less than 32 weeks’ gestation or birth weight below 1500 g; or neonates born with 32–37 weeks’ gestation or birth weight above 1500 g and any of the following associated: multiple gestation, respiratory distress syndrome, sepsis, blood transfusions or intraventricular hemorrhage. Neonates were followed up until disease resolution or until treatment criteria was achieved. Results A total of 602 newborns were evaluated after applying the exclusion criteria. Mean gestational age was 30.7 ± 2.5 weeks. The incidences of ROP at any stage and of type 1 prethreshold ROP were 33.9 and 5.0% respectively. Logistic regression analysis revealed that risk factors associated with ROP at any stage were extremely low birth weight (ELBW) (odds ratio [OR] = 3.10; 95% confidence interval [95% CI]:1.73–5.55), pulmonary diseases (OR = 2.49; 95% CI: 1.35–4.59), intraventricular hemorrhage (OR = 2.17; 95% CI: 1.10–4.30), and low gestational age (OR = 0.81; 95% CI: 0.73–0.91). The main risk factors associated with type 1 prethreshold ROP were pulmonary diseases (OR = 9.58; 95% CI: 1.27–72.04) and ELBW (OR = 3.66; 95% CI: 1.67–8.00). Conclusion This study found a significant incidence of ROP (33.9%) in the studied population, and highlighted pulmonary diseases as a significant risk factor for type 1 prethreshold ROP.http://link.springer.com/article/10.1186/s40942-018-0125-zPremature birthExtremely preterm infantNeonateRetinopathy of prematurityIntensive care units, pediatric |
| spellingShingle | André Moraes Freitas Ricardo Mörschbächer Mariana R. Thorell Ernani Luis Rhoden Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study International Journal of Retina and Vitreous Premature birth Extremely preterm infant Neonate Retinopathy of prematurity Intensive care units, pediatric |
| title | Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study |
| title_full | Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study |
| title_fullStr | Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study |
| title_full_unstemmed | Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study |
| title_short | Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study |
| title_sort | incidence and risk factors for retinopathy of prematurity a retrospective cohort study |
| topic | Premature birth Extremely preterm infant Neonate Retinopathy of prematurity Intensive care units, pediatric |
| url | http://link.springer.com/article/10.1186/s40942-018-0125-z |
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