Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes
Acute hyperglycemia has been shown to cause cognitive impairments in animal models. There is growing appreciation of the numerous effects of hyperglycemia on neuronal function as well as blood–brain barrier function. In humans, hypoglycemia is well known to cause cognitive deficits acutely, but hype...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2017-12-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0101 |
| _version_ | 1818270288872210432 |
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| author | Joseph Cerasuolo Anthony Izzo |
| author_facet | Joseph Cerasuolo Anthony Izzo |
| author_sort | Joseph Cerasuolo |
| collection | DOAJ |
| description | Acute hyperglycemia has been shown to cause cognitive impairments in animal models. There is growing appreciation of the numerous effects of hyperglycemia on neuronal function as well as blood–brain barrier function. In humans, hypoglycemia is well known to cause cognitive deficits acutely, but hyperglycemia has been less well studied. We present a case of selective neurocognitive deficits in the setting of acute hyperglycemia. A 60-year-old man was admitted to the hospital for an episode of acute hyperglycemia in the setting of newly diagnosed diabetes mellitus precipitated by steroid use. He was managed with insulin therapy and discharged home, and later, presented with complaints of memory impairment. Deficits included impairment in his declarative and working memory, to the point of significant impairment in his overall functioning. The patient had no structural lesions on MRI imaging of the brain or other systemic illnesses to explain his specific deficits. We suggest that his acute hyperglycemia may have caused neurological injury, and may be responsible for our patient’s memory complaints. |
| first_indexed | 2024-12-12T21:07:54Z |
| format | Article |
| id | doaj.art-a359dbd91bd44a6eb826bc5a0a0c52f0 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 2052-0573 |
| language | English |
| last_indexed | 2024-12-12T21:07:54Z |
| publishDate | 2017-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-a359dbd91bd44a6eb826bc5a0a0c52f02022-12-22T00:11:59ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732017-12-01111410.1530/EDM-17-0101Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetesJoseph Cerasuolo0Anthony Izzo1Department of Neurology and Department of Internal Medicine, St. Vincent Hospital, Worcester, Massachusetts, USADepartment of Neurology and Department of Internal Medicine, St. Vincent Hospital, Worcester, Massachusetts, USAAcute hyperglycemia has been shown to cause cognitive impairments in animal models. There is growing appreciation of the numerous effects of hyperglycemia on neuronal function as well as blood–brain barrier function. In humans, hypoglycemia is well known to cause cognitive deficits acutely, but hyperglycemia has been less well studied. We present a case of selective neurocognitive deficits in the setting of acute hyperglycemia. A 60-year-old man was admitted to the hospital for an episode of acute hyperglycemia in the setting of newly diagnosed diabetes mellitus precipitated by steroid use. He was managed with insulin therapy and discharged home, and later, presented with complaints of memory impairment. Deficits included impairment in his declarative and working memory, to the point of significant impairment in his overall functioning. The patient had no structural lesions on MRI imaging of the brain or other systemic illnesses to explain his specific deficits. We suggest that his acute hyperglycemia may have caused neurological injury, and may be responsible for our patient’s memory complaints.https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0101 |
| spellingShingle | Joseph Cerasuolo Anthony Izzo Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes Endocrinology, Diabetes & Metabolism Case Reports |
| title | Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes |
| title_full | Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes |
| title_fullStr | Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes |
| title_full_unstemmed | Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes |
| title_short | Persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes |
| title_sort | persistent impairment in working memory following severe hyperglycemia in newly diagnosed type 2 diabetes |
| url | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0101 |
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