Multicolour imaging with spectral photon-counting CT: a phantom study
Abstract Background To evaluate the feasibility of multicolour quantitative imaging with spectral photon-counting computed tomography (SPCCT) of different mixed contrast agents. Methods Phantoms containing eleven tubes with mixtures of varying proportions of two contrast agents (i.e. two selected fr...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-10-01
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| Series: | European Radiology Experimental |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41747-018-0063-4 |
| _version_ | 1818217590920577024 |
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| author | Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Valérie Tatard-Leitman David P. Cormode Pratap C. Naha Philippe Coulon Lucie Rascle Ewald Roessl Michal Rokni Ami Altman Yoad Yagil Loic Boussel Philippe Douek |
| author_facet | Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Valérie Tatard-Leitman David P. Cormode Pratap C. Naha Philippe Coulon Lucie Rascle Ewald Roessl Michal Rokni Ami Altman Yoad Yagil Loic Boussel Philippe Douek |
| author_sort | Salim Si-Mohamed |
| collection | DOAJ |
| description | Abstract Background To evaluate the feasibility of multicolour quantitative imaging with spectral photon-counting computed tomography (SPCCT) of different mixed contrast agents. Methods Phantoms containing eleven tubes with mixtures of varying proportions of two contrast agents (i.e. two selected from gadolinium, iodine or gold nanoparticles) were prepared so that the attenuation of each tube was about 280 HU. Scans were acquired at 120 kVp and 100 mAs using a five-bin preclinical SPCCT prototype, generating conventional, water, iodine, gadolinium and gold images. The correlation between prepared and measured concentrations was assessed using linear regression. The cross-contamination was measured for each material as the root mean square error (RMSE) of its concentration in the other material images, where no signal was expected. The contrast-to-noise ratio (CNR) relative to a phosphate buffered saline tube was calculated for each contrast agent. Results The solutions had similar attenuations (279 ± 10 HU, mean ± standard deviation) and could not be differentiated on conventional images. However, a distinction was observed in the material images within the same samples, and the measured and prepared concentrations were strongly correlated (R2 ≥ 0.97, 0.81 ≤ slope ≤ 0.95, -0.68 ≤ offset ≤ 0.89 mg/mL). Cross-contamination in the iodine images for the mixture of gold and gadolinium contrast agents (RMSE = 0.34 mg/mL) was observed. CNR for 1 mg/mL of contrast agent was better for the mixture of iodine and gadolinium (CNRiodine = 3.20, CNRgadolinium = 2.80) than gold and gadolinium (CNRgadolinium = 1.67, CNRgold = 1.37). Conclusions SPCCT enables multicolour quantitative imaging. As a result, it should be possible to perform imaging of multiple uptake phases of a given tissue/organ within a single scan by injecting different contrast agents sequentially. |
| first_indexed | 2024-12-12T07:10:18Z |
| format | Article |
| id | doaj.art-a35c8afc639a40aead2cae487ed9b92c |
| institution | Directory Open Access Journal |
| issn | 2509-9280 |
| language | English |
| last_indexed | 2024-12-12T07:10:18Z |
| publishDate | 2018-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj.art-a35c8afc639a40aead2cae487ed9b92c2022-12-22T00:33:39ZengSpringerOpenEuropean Radiology Experimental2509-92802018-10-012111010.1186/s41747-018-0063-4Multicolour imaging with spectral photon-counting CT: a phantom studySalim Si-Mohamed0Daniel Bar-Ness1Monica Sigovan2Valérie Tatard-Leitman3David P. Cormode4Pratap C. Naha5Philippe Coulon6Lucie Rascle7Ewald Roessl8Michal Rokni9Ami Altman10Yoad Yagil11Loic Boussel12Philippe Douek13University Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonUniversity Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonUniversity Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonUniversity Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaCT Clinical Science, PhilipsUniversity Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonPhilips GmbH Innovative Technologies, Research LaboratoriesGlobal Advanced Technologies, CT, PhilipsGlobal Advanced Technologies, CT, PhilipsGlobal Advanced Technologies, CT, PhilipsUniversity Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonUniversity Claude Bernard Lyon1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-LyonAbstract Background To evaluate the feasibility of multicolour quantitative imaging with spectral photon-counting computed tomography (SPCCT) of different mixed contrast agents. Methods Phantoms containing eleven tubes with mixtures of varying proportions of two contrast agents (i.e. two selected from gadolinium, iodine or gold nanoparticles) were prepared so that the attenuation of each tube was about 280 HU. Scans were acquired at 120 kVp and 100 mAs using a five-bin preclinical SPCCT prototype, generating conventional, water, iodine, gadolinium and gold images. The correlation between prepared and measured concentrations was assessed using linear regression. The cross-contamination was measured for each material as the root mean square error (RMSE) of its concentration in the other material images, where no signal was expected. The contrast-to-noise ratio (CNR) relative to a phosphate buffered saline tube was calculated for each contrast agent. Results The solutions had similar attenuations (279 ± 10 HU, mean ± standard deviation) and could not be differentiated on conventional images. However, a distinction was observed in the material images within the same samples, and the measured and prepared concentrations were strongly correlated (R2 ≥ 0.97, 0.81 ≤ slope ≤ 0.95, -0.68 ≤ offset ≤ 0.89 mg/mL). Cross-contamination in the iodine images for the mixture of gold and gadolinium contrast agents (RMSE = 0.34 mg/mL) was observed. CNR for 1 mg/mL of contrast agent was better for the mixture of iodine and gadolinium (CNRiodine = 3.20, CNRgadolinium = 2.80) than gold and gadolinium (CNRgadolinium = 1.67, CNRgold = 1.37). Conclusions SPCCT enables multicolour quantitative imaging. As a result, it should be possible to perform imaging of multiple uptake phases of a given tissue/organ within a single scan by injecting different contrast agents sequentially.http://link.springer.com/article/10.1186/s41747-018-0063-4GadoliniumGoldIodinePhantoms (imaging)Tomography (x-ray computed) |
| spellingShingle | Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Valérie Tatard-Leitman David P. Cormode Pratap C. Naha Philippe Coulon Lucie Rascle Ewald Roessl Michal Rokni Ami Altman Yoad Yagil Loic Boussel Philippe Douek Multicolour imaging with spectral photon-counting CT: a phantom study European Radiology Experimental Gadolinium Gold Iodine Phantoms (imaging) Tomography (x-ray computed) |
| title | Multicolour imaging with spectral photon-counting CT: a phantom study |
| title_full | Multicolour imaging with spectral photon-counting CT: a phantom study |
| title_fullStr | Multicolour imaging with spectral photon-counting CT: a phantom study |
| title_full_unstemmed | Multicolour imaging with spectral photon-counting CT: a phantom study |
| title_short | Multicolour imaging with spectral photon-counting CT: a phantom study |
| title_sort | multicolour imaging with spectral photon counting ct a phantom study |
| topic | Gadolinium Gold Iodine Phantoms (imaging) Tomography (x-ray computed) |
| url | http://link.springer.com/article/10.1186/s41747-018-0063-4 |
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