Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging
The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammatio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1324429/full |
| _version_ | 1797392884506296320 |
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| author | Makoto Orisaka Tetsuya Mizutani Yumiko Miyazaki Aya Shirafuji Chiyo Tamamura Masayuki Fujita Hideaki Tsuyoshi Hideaki Tsuyoshi Yoshio Yoshida |
| author_facet | Makoto Orisaka Tetsuya Mizutani Yumiko Miyazaki Aya Shirafuji Chiyo Tamamura Masayuki Fujita Hideaki Tsuyoshi Hideaki Tsuyoshi Yoshio Yoshida |
| author_sort | Makoto Orisaka |
| collection | DOAJ |
| description | The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction. |
| first_indexed | 2024-03-08T23:54:58Z |
| format | Article |
| id | doaj.art-a35cefe6ee0c48fdba5fe6d9d7baf5d0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T23:54:58Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a35cefe6ee0c48fdba5fe6d9d7baf5d02023-12-13T05:48:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.13244291324429Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and agingMakoto Orisaka0Tetsuya Mizutani1Yumiko Miyazaki2Aya Shirafuji3Chiyo Tamamura4Masayuki Fujita5Hideaki Tsuyoshi6Hideaki Tsuyoshi7Yoshio Yoshida8Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Nursing, Faculty of Nursing and Welfare Sciences, Fukui Prefectural University, Fukui, JapanDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Obstetrics and Gynecology, Ishikawa Prefectural Central Hospital, Ishikawa, JapanDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, JapanThe ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.https://www.frontiersin.org/articles/10.3389/fendo.2023.1324429/fullagingendometriosisfollicular microenvironmentinflammationovarian dysfunctionpolycystic ovarian syndrome |
| spellingShingle | Makoto Orisaka Tetsuya Mizutani Yumiko Miyazaki Aya Shirafuji Chiyo Tamamura Masayuki Fujita Hideaki Tsuyoshi Hideaki Tsuyoshi Yoshio Yoshida Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging Frontiers in Endocrinology aging endometriosis follicular microenvironment inflammation ovarian dysfunction polycystic ovarian syndrome |
| title | Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging |
| title_full | Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging |
| title_fullStr | Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging |
| title_full_unstemmed | Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging |
| title_short | Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging |
| title_sort | chronic low grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome endometriosis and aging |
| topic | aging endometriosis follicular microenvironment inflammation ovarian dysfunction polycystic ovarian syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1324429/full |
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