| Summary: | Background: Parkinson’s disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both <i>ADORA2A rs5760423</i> and <i>CYP1A2 rs762551</i> have been linked to PD, to some extent, but the exact role of those polymorphisms in PD remains controversial. Objective: We assessed the role of <i>ADORA2A rs5760423</i> and <i>CYP1A2 rs762551</i> on PD risk. Methods: We genotyped 358 patients with PD and 358 healthy controls for <i>ADORA2A rs5760423</i> and <i>CYP1A2 rs762551</i>. We also merged and meta-analyzed our data with data from previous studies, regarding these two polymorphisms and PD. Results: No significant association with PD was revealed (<i>p</i> > 0.05), for either <i>ADORA2A rs5760423</i> or <i>CYP1A2 rs762551</i>, in any of the examined genetic model of inheritance. In addition, results from meta-analyses yield negative results. Conclusions: Based on our analyses, it appears rather unlikely that <i>ADORA2A rs5760423</i> or <i>CYP1A2 rs762551</i> is among the major risk factors for PD, at least in Greek patients with PD.
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