Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse mode...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-020-01590-0 |
| _version_ | 1831766983881785344 |
|---|---|
| author | Xiaoding Hu Emilly S. Villodre Richard Larson Omar M. Rahal Xiaoping Wang Yun Gong Juhee Song Savitri Krishnamurthy Naoto T. Ueno Debu Tripathy Wendy A. Woodward Bisrat G. Debeb |
| author_facet | Xiaoding Hu Emilly S. Villodre Richard Larson Omar M. Rahal Xiaoping Wang Yun Gong Juhee Song Savitri Krishnamurthy Naoto T. Ueno Debu Tripathy Wendy A. Woodward Bisrat G. Debeb |
| author_sort | Xiaoding Hu |
| collection | DOAJ |
| description | Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer. |
| first_indexed | 2024-12-22T06:32:46Z |
| format | Article |
| id | doaj.art-a35e725f4a31444ab59fa8714d1e455f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-22T06:32:46Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a35e725f4a31444ab59fa8714d1e455f2022-12-21T18:35:39ZengNature PortfolioCommunications Biology2399-36422021-01-014111410.1038/s42003-020-01590-0Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancerXiaoding Hu0Emilly S. Villodre1Richard Larson2Omar M. Rahal3Xiaoping Wang4Yun Gong5Juhee Song6Savitri Krishnamurthy7Naoto T. Ueno8Debu Tripathy9Wendy A. Woodward10Bisrat G. Debeb11Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterMorgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, the University of Texas MD Anderson Cancer CenterXiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer.https://doi.org/10.1038/s42003-020-01590-0 |
| spellingShingle | Xiaoding Hu Emilly S. Villodre Richard Larson Omar M. Rahal Xiaoping Wang Yun Gong Juhee Song Savitri Krishnamurthy Naoto T. Ueno Debu Tripathy Wendy A. Woodward Bisrat G. Debeb Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer Communications Biology |
| title | Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer |
| title_full | Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer |
| title_fullStr | Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer |
| title_full_unstemmed | Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer |
| title_short | Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer |
| title_sort | decorin mediated suppression of tumorigenesis invasion and metastasis in inflammatory breast cancer |
| url | https://doi.org/10.1038/s42003-020-01590-0 |
| work_keys_str_mv | AT xiaodinghu decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT emillysvillodre decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT richardlarson decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT omarmrahal decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT xiaopingwang decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT yungong decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT juheesong decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT savitrikrishnamurthy decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT naototueno decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT debutripathy decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT wendyawoodward decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer AT bisratgdebeb decorinmediatedsuppressionoftumorigenesisinvasionandmetastasisininflammatorybreastcancer |