Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma

Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma

Sodium iodide symporter (NIS) gene transfer for active accumulation of iodide in tumor cells is a powerful theranostic strategy facilitating both diagnostic and therapeutic application of radioiodide. In glioblastoma (GBM), the blood-brain barrier (BBB) presents an additional delivery barrier for nu...

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Bibliographic Details
Main Authors: Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Mara Hageneier, Nathalie Schwenk, Özgür Öztürk, Katja Steiger, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Roland E. Kälin, Rainer Glass, Peter J. Nelson, Ernst Wagner, Christine Spitzweg
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
sodium iodide symporter
NIS
radioiodine
blood-brain barrier
EGFR
transferrin receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001358

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http://www.sciencedirect.com/science/article/pii/S2372770522001358

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