mTOR Inhibitor Rapalink-1 Prevents Ethanol-Induced Senescence in Endothelial Cells

mTOR Inhibitor Rapalink-1 Prevents Ethanol-Induced Senescence in Endothelial Cells

The cardiovascular risk factors, including smoking, ethanol, and oxidative stress, can induce cellular senescence. The senescent cells increase the expression and release of pro-inflammatory molecules and matrix metalloproteinase (MMPs). These pro-inflammatory molecules and MMPs promote the infiltra...

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Bibliographic Details
Main Authors: Huakang Zhou, Xuanchen Li, Majeed Rana, Jan Frederick Cornelius, Dilaware Khan, Sajjad Muhammad
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
ethanol
endothelial cells
senescence
SASP
Rapalink-1
NFκ-B
Online Access:https://www.mdpi.com/2073-4409/12/22/2609

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