Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis
Abstract Background Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet in many parts of the world its magnitude is not well elucidated. A baseline assessment of the AMR prevalence is a priority for implementation of laboratory-based AMR surveillance This review, fo...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Public Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12889-019-7450-5 |
| _version_ | 1818435659003592704 |
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| author | Mohamed Moctar Mouliom Mouiche Frédéric Moffo Jane-Francis Tatah Kihla Akoachere Ndode Herman Okah-Nnane Nabilah Pemi Mapiefou Valantine Ngum Ndze Abel Wade Félicité Flore Djuikwo-Teukeng Dorine Godelive Tseuko Toghoua Henri René Zambou Jean Marc Kameni Feussom Matthew LeBreton Julius Awah-Ndukum |
| author_facet | Mohamed Moctar Mouliom Mouiche Frédéric Moffo Jane-Francis Tatah Kihla Akoachere Ndode Herman Okah-Nnane Nabilah Pemi Mapiefou Valantine Ngum Ndze Abel Wade Félicité Flore Djuikwo-Teukeng Dorine Godelive Tseuko Toghoua Henri René Zambou Jean Marc Kameni Feussom Matthew LeBreton Julius Awah-Ndukum |
| author_sort | Mohamed Moctar Mouliom Mouiche |
| collection | DOAJ |
| description | Abstract Background Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet in many parts of the world its magnitude is not well elucidated. A baseline assessment of the AMR prevalence is a priority for implementation of laboratory-based AMR surveillance This review, focused on a One health approach, aimed at describing the current status of AMR in Cameroon. Methods PubMed, Google Scholar and African Journals Online databases were searched for articles published in English and French in accordance with the PRISMA guidelines. Retrieval and screening of article was done using a structured search string with strict inclusion/exclusion criteria. Free-text and grey literature were obtained by contacting the authors directly. The pooled prevalence and 95% confidence intervals were calculated for each pathogen–antibiotic pairs using random-effects models. Result Amongst 97 full-text articles reviewed, 66 met the eligibility criteria. The studies originated from the Centre (24; 36.4%), South-West (16; 24.2%), West (13; 19.7%), Littoral (9; 13.6%) and other (4; 6.1%) regions of Cameroon. These studies reported AMR in human (45; 68.2%), animals (9; 13.6%) and the environment (12; 18.2%). Overall, 19 species of bacteria were tested against 48 antibiotics. These organisms were resistant to all classes of antibiotics and showed high levels of multidrug resistance. Escherichia coli, Klebsiella pneumoniae and Staphylococcus spp were reported in 23, 19 and 18 of the human studies and revealed multidrug resistance (MDR) rates of 47.1% [95% CI (37.3–57.2%)], 51.0% [95% CI (42.0–59.9)] and 45.2% [95% CI (38.0–54.7)], respectively. Salmonella spp was reported in 6 of the animal studies and showed a MDR rate of 46.2% [95% CI (39.2–53.5%)] while Staphylococcus spp in 8 of environment studies showed MDR rate of 67.1% [95% CI (55.2–77.2%)]. Conclusion This review shows that resistance to commonly prescribed antibiotics in Cameroon is high. The findings emphasize the urgent need to address gaps in the standardization of AMR diagnostics, reporting and use of available information to optimize treatment guidelines for the arsenal of antibiotics. Effective AMR surveillance through continued data sharing, large-scale collaboration, and coordination of all stakeholders is essential to understand and manage the AMR national burden. |
| first_indexed | 2024-12-14T16:56:24Z |
| format | Article |
| id | doaj.art-a3681d6e1aa14c04aef31d9976b8de25 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-14T16:56:24Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-a3681d6e1aa14c04aef31d9976b8de252022-12-21T22:53:58ZengBMCBMC Public Health1471-24582019-08-0119112010.1186/s12889-019-7450-5Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysisMohamed Moctar Mouliom Mouiche0Frédéric Moffo1Jane-Francis Tatah Kihla Akoachere2Ndode Herman Okah-Nnane3Nabilah Pemi Mapiefou4Valantine Ngum Ndze5Abel Wade6Félicité Flore Djuikwo-Teukeng7Dorine Godelive Tseuko Toghoua8Henri René Zambou9Jean Marc Kameni Feussom10Matthew LeBreton11Julius Awah-Ndukum12Department of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of NgaoundéréDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of NgaoundéréDepartment of Microbiology and Parasitology, Faculty of Science, University of BueaDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of NgaoundéréDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of NgaoundéréJohns Hopkins Cameroon ProgramNational Veterinary Laboratory (LANAVET)Faculty of Heath Science, Université des MontagnesNational Public Health Laboratory (LNSP)Epidemiology-Public Health-Veterinary Association (ESPV)Epidemiology-Public Health-Veterinary Association (ESPV)MOSAICDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of NgaoundéréAbstract Background Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet in many parts of the world its magnitude is not well elucidated. A baseline assessment of the AMR prevalence is a priority for implementation of laboratory-based AMR surveillance This review, focused on a One health approach, aimed at describing the current status of AMR in Cameroon. Methods PubMed, Google Scholar and African Journals Online databases were searched for articles published in English and French in accordance with the PRISMA guidelines. Retrieval and screening of article was done using a structured search string with strict inclusion/exclusion criteria. Free-text and grey literature were obtained by contacting the authors directly. The pooled prevalence and 95% confidence intervals were calculated for each pathogen–antibiotic pairs using random-effects models. Result Amongst 97 full-text articles reviewed, 66 met the eligibility criteria. The studies originated from the Centre (24; 36.4%), South-West (16; 24.2%), West (13; 19.7%), Littoral (9; 13.6%) and other (4; 6.1%) regions of Cameroon. These studies reported AMR in human (45; 68.2%), animals (9; 13.6%) and the environment (12; 18.2%). Overall, 19 species of bacteria were tested against 48 antibiotics. These organisms were resistant to all classes of antibiotics and showed high levels of multidrug resistance. Escherichia coli, Klebsiella pneumoniae and Staphylococcus spp were reported in 23, 19 and 18 of the human studies and revealed multidrug resistance (MDR) rates of 47.1% [95% CI (37.3–57.2%)], 51.0% [95% CI (42.0–59.9)] and 45.2% [95% CI (38.0–54.7)], respectively. Salmonella spp was reported in 6 of the animal studies and showed a MDR rate of 46.2% [95% CI (39.2–53.5%)] while Staphylococcus spp in 8 of environment studies showed MDR rate of 67.1% [95% CI (55.2–77.2%)]. Conclusion This review shows that resistance to commonly prescribed antibiotics in Cameroon is high. The findings emphasize the urgent need to address gaps in the standardization of AMR diagnostics, reporting and use of available information to optimize treatment guidelines for the arsenal of antibiotics. Effective AMR surveillance through continued data sharing, large-scale collaboration, and coordination of all stakeholders is essential to understand and manage the AMR national burden.http://link.springer.com/article/10.1186/s12889-019-7450-5Antimicrobial resistanceBacteriaOne healthHumanAnimalEnvironment |
| spellingShingle | Mohamed Moctar Mouliom Mouiche Frédéric Moffo Jane-Francis Tatah Kihla Akoachere Ndode Herman Okah-Nnane Nabilah Pemi Mapiefou Valantine Ngum Ndze Abel Wade Félicité Flore Djuikwo-Teukeng Dorine Godelive Tseuko Toghoua Henri René Zambou Jean Marc Kameni Feussom Matthew LeBreton Julius Awah-Ndukum Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis BMC Public Health Antimicrobial resistance Bacteria One health Human Animal Environment |
| title | Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis |
| title_full | Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis |
| title_fullStr | Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis |
| title_full_unstemmed | Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis |
| title_short | Antimicrobial resistance from a one health perspective in Cameroon: a systematic review and meta-analysis |
| title_sort | antimicrobial resistance from a one health perspective in cameroon a systematic review and meta analysis |
| topic | Antimicrobial resistance Bacteria One health Human Animal Environment |
| url | http://link.springer.com/article/10.1186/s12889-019-7450-5 |
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