Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

Objective: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effe...

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Bibliographic Details
Main Authors: Jennifer M. Brazill, David Shin, Kristann Magee, Anurag Majumdar, Ivana R. Shen, Valeria Cavalli, Erica L. Scheller
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Molecular Metabolism
Subjects:
mTOR
Bone
High fat diet
Skinny fat
Normal weight obesity
Sensory nerve
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002332

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