Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease
Activation and increased numbers of inflammatory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases. Up to now, AT macrophages (ATM) accumulation was considered to be due to blood infiltration or local proliferation, although the presence of resident hematopoietic stem/progeni...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-06-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/23194 |
| _version_ | 1811181187145662464 |
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| author | Elodie Luche Virginie Robert Vincent Cuminetti Celine Pomié Quentin Sastourné-Arrey Aurélie Waget Emmanuelle Arnaud Audrey Varin Elodie Labit Patrick Laharrague Remy Burcelin Louis Casteilla Beatrice Cousin |
| author_facet | Elodie Luche Virginie Robert Vincent Cuminetti Celine Pomié Quentin Sastourné-Arrey Aurélie Waget Emmanuelle Arnaud Audrey Varin Elodie Labit Patrick Laharrague Remy Burcelin Louis Casteilla Beatrice Cousin |
| author_sort | Elodie Luche |
| collection | DOAJ |
| description | Activation and increased numbers of inflammatory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases. Up to now, AT macrophages (ATM) accumulation was considered to be due to blood infiltration or local proliferation, although the presence of resident hematopoietic stem/progenitor cells (Lin-/Sca+/c-Kit+; LSK phenotype) in the AT (AT-LSK) has been reported. By using transplantation of sorted AT-LSK and gain and loss of function studies we show that some of the inflammatory ATM inducing metabolic disease, originate from resident AT-LSK. Transplantation of AT-LSK sorted from high fat diet-fed (HFD) mice is sufficient to induce ATM accumulation, and to transfer metabolic disease in control mice. Conversely, the transplantation of control AT-LSK improves both AT-inflammation and glucose homeostasis in HFD mice. Our results clearly demonstrate that resident AT-LSK are one of the key point of metabolic disease, and could thus constitute a new promising therapeutic target to fight against metabolic disease. |
| first_indexed | 2024-04-11T09:15:11Z |
| format | Article |
| id | doaj.art-a36efdf50ddf4a528c94d1e075a61494 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:15:11Z |
| publishDate | 2017-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a36efdf50ddf4a528c94d1e075a614942022-12-22T04:32:24ZengeLife Sciences Publications LtdeLife2050-084X2017-06-01610.7554/eLife.23194Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic diseaseElodie Luche0Virginie Robert1Vincent Cuminetti2Celine Pomié3Quentin Sastourné-Arrey4Aurélie Waget5Emmanuelle Arnaud6Audrey Varin7Elodie Labit8Patrick Laharrague9Remy Burcelin10Louis Casteilla11Beatrice Cousin12https://orcid.org/0000-0003-2952-4601STROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceINSERM U1048, Université de Toulouse, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceINSERM U1048, Université de Toulouse, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceINSERM U1048, Université de Toulouse, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL 5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceActivation and increased numbers of inflammatory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases. Up to now, AT macrophages (ATM) accumulation was considered to be due to blood infiltration or local proliferation, although the presence of resident hematopoietic stem/progenitor cells (Lin-/Sca+/c-Kit+; LSK phenotype) in the AT (AT-LSK) has been reported. By using transplantation of sorted AT-LSK and gain and loss of function studies we show that some of the inflammatory ATM inducing metabolic disease, originate from resident AT-LSK. Transplantation of AT-LSK sorted from high fat diet-fed (HFD) mice is sufficient to induce ATM accumulation, and to transfer metabolic disease in control mice. Conversely, the transplantation of control AT-LSK improves both AT-inflammation and glucose homeostasis in HFD mice. Our results clearly demonstrate that resident AT-LSK are one of the key point of metabolic disease, and could thus constitute a new promising therapeutic target to fight against metabolic disease.https://elifesciences.org/articles/23194adipose tissuediabetesmacrophageshematopoiesis |
| spellingShingle | Elodie Luche Virginie Robert Vincent Cuminetti Celine Pomié Quentin Sastourné-Arrey Aurélie Waget Emmanuelle Arnaud Audrey Varin Elodie Labit Patrick Laharrague Remy Burcelin Louis Casteilla Beatrice Cousin Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease eLife adipose tissue diabetes macrophages hematopoiesis |
| title | Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease |
| title_full | Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease |
| title_fullStr | Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease |
| title_full_unstemmed | Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease |
| title_short | Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease |
| title_sort | corrupted adipose tissue endogenous myelopoiesis initiates diet induced metabolic disease |
| topic | adipose tissue diabetes macrophages hematopoiesis |
| url | https://elifesciences.org/articles/23194 |
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