Endothelial Cell Dysfunction in Viral Hemorrhage and Edema
The endothelium maintains a vascular barrier by controlling platelet and immune cell interactions, capillary tone and interendothelial cell adherence. Here we suggest common elements in play during viral infection of the endothelium that alter normal endothelial cell functions and contribute to leth...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00733/full |
| _version_ | 1811212140466405376 |
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| author | Erich Reuter Mackow Elena E Gorbunova Irina N. Gavrilovskaya |
| author_facet | Erich Reuter Mackow Elena E Gorbunova Irina N. Gavrilovskaya |
| author_sort | Erich Reuter Mackow |
| collection | DOAJ |
| description | The endothelium maintains a vascular barrier by controlling platelet and immune cell interactions, capillary tone and interendothelial cell adherence. Here we suggest common elements in play during viral infection of the endothelium that alter normal endothelial cell functions and contribute to lethal hemorrhagic or edematous diseases. In viral reservoir hosts, infection of capillaries and lymphatic vessels may direct immunotolerance without disease, but in the absence of these cognate interactions they direct the delayed onset of human disease characterized by thrombocytopenia and vascular leakage in a severe endothelial dysfunction syndrome. Here we present insight into endothelial cell controls of hemostasis, immune response and capillary permeability that are altered by viral infection of the endothelium. |
| first_indexed | 2024-04-12T05:24:55Z |
| format | Article |
| id | doaj.art-a3705a72b49441a7b7653da39d3a1758 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T05:24:55Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a3705a72b49441a7b7653da39d3a17582022-12-22T03:46:20ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-01-01510.3389/fmicb.2014.00733122417Endothelial Cell Dysfunction in Viral Hemorrhage and EdemaErich Reuter Mackow0Elena E Gorbunova1Irina N. Gavrilovskaya2Stony Brook UniversityStony Brook UniversityStony Brook UniversityThe endothelium maintains a vascular barrier by controlling platelet and immune cell interactions, capillary tone and interendothelial cell adherence. Here we suggest common elements in play during viral infection of the endothelium that alter normal endothelial cell functions and contribute to lethal hemorrhagic or edematous diseases. In viral reservoir hosts, infection of capillaries and lymphatic vessels may direct immunotolerance without disease, but in the absence of these cognate interactions they direct the delayed onset of human disease characterized by thrombocytopenia and vascular leakage in a severe endothelial dysfunction syndrome. Here we present insight into endothelial cell controls of hemostasis, immune response and capillary permeability that are altered by viral infection of the endothelium.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00733/fullArenavirusDengueHantavirusendothelialPlateletPD-L1 |
| spellingShingle | Erich Reuter Mackow Elena E Gorbunova Irina N. Gavrilovskaya Endothelial Cell Dysfunction in Viral Hemorrhage and Edema Frontiers in Microbiology Arenavirus Dengue Hantavirus endothelial Platelet PD-L1 |
| title | Endothelial Cell Dysfunction in Viral Hemorrhage and Edema |
| title_full | Endothelial Cell Dysfunction in Viral Hemorrhage and Edema |
| title_fullStr | Endothelial Cell Dysfunction in Viral Hemorrhage and Edema |
| title_full_unstemmed | Endothelial Cell Dysfunction in Viral Hemorrhage and Edema |
| title_short | Endothelial Cell Dysfunction in Viral Hemorrhage and Edema |
| title_sort | endothelial cell dysfunction in viral hemorrhage and edema |
| topic | Arenavirus Dengue Hantavirus endothelial Platelet PD-L1 |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00733/full |
| work_keys_str_mv | AT erichreutermackow endothelialcelldysfunctioninviralhemorrhageandedema AT elenaegorbunova endothelialcelldysfunctioninviralhemorrhageandedema AT irinangavrilovskaya endothelialcelldysfunctioninviralhemorrhageandedema |