Novel Targeted Therapeutic Strategies for Ewing Sarcoma
Ewing sarcoma (ES) is an uncommon cancer that arises in mesenchymal tissues and represents the second most widespread malignant bone neoplasm after osteosarcoma in children. Amplifications in genomic, proteomic, and metabolism are characteristics of sarcoma, and targeting altered cancer cell molecul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/8/1988 |
| _version_ | 1797436494259945472 |
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| author | Daria Fayzullina Sergey Tsibulnikov Mikhail Stempen Brett A. Schroeder Naveen Kumar Rajesh Kumar Kharwar Arbind Acharya Peter Timashev Ilya Ulasov |
| author_facet | Daria Fayzullina Sergey Tsibulnikov Mikhail Stempen Brett A. Schroeder Naveen Kumar Rajesh Kumar Kharwar Arbind Acharya Peter Timashev Ilya Ulasov |
| author_sort | Daria Fayzullina |
| collection | DOAJ |
| description | Ewing sarcoma (ES) is an uncommon cancer that arises in mesenchymal tissues and represents the second most widespread malignant bone neoplasm after osteosarcoma in children. Amplifications in genomic, proteomic, and metabolism are characteristics of sarcoma, and targeting altered cancer cell molecular processes has been proposed as the latest promising strategy to fight cancer. Recent technological advancements have elucidated some of the underlying oncogenic characteristics of Ewing sarcoma. Offering new insights into the physiological basis for this phenomenon, our current review examines the dynamics of ES signaling as it related to both ES and the microenvironment by integrating genomic and proteomic analyses. An extensive survey of the literature was performed to compile the findings. We have also highlighted recent and ongoing studies integrating metabolomics and genomics aimed at better understanding the complex interactions as to how ES adapts to changing biochemical changes within the tumor microenvironment. |
| first_indexed | 2024-03-09T11:03:29Z |
| format | Article |
| id | doaj.art-a3714dc278b748feb94c55b68dde5449 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T11:03:29Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a3714dc278b748feb94c55b68dde54492023-12-01T01:07:51ZengMDPI AGCancers2072-66942022-04-01148198810.3390/cancers14081988Novel Targeted Therapeutic Strategies for Ewing SarcomaDaria Fayzullina0Sergey Tsibulnikov1Mikhail Stempen2Brett A. Schroeder3Naveen Kumar4Rajesh Kumar Kharwar5Arbind Acharya6Peter Timashev7Ilya Ulasov8Group of Experimental Biotherapy and Diagnostic, Department of Advanced Materials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow 119991, RussiaGroup of Experimental Biotherapy and Diagnostic, Department of Advanced Materials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow 119991, RussiaGroup of Experimental Biotherapy and Diagnostic, Department of Advanced Materials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow 119991, RussiaNational Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USATumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, IndiaEndocrine Research Lab, Department of Zoology, Kutir Post Graduate College, Chakkey, Jaunpur 222146, IndiaTumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, IndiaWorld-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University, Moscow 119991, RussiaGroup of Experimental Biotherapy and Diagnostic, Department of Advanced Materials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow 119991, RussiaEwing sarcoma (ES) is an uncommon cancer that arises in mesenchymal tissues and represents the second most widespread malignant bone neoplasm after osteosarcoma in children. Amplifications in genomic, proteomic, and metabolism are characteristics of sarcoma, and targeting altered cancer cell molecular processes has been proposed as the latest promising strategy to fight cancer. Recent technological advancements have elucidated some of the underlying oncogenic characteristics of Ewing sarcoma. Offering new insights into the physiological basis for this phenomenon, our current review examines the dynamics of ES signaling as it related to both ES and the microenvironment by integrating genomic and proteomic analyses. An extensive survey of the literature was performed to compile the findings. We have also highlighted recent and ongoing studies integrating metabolomics and genomics aimed at better understanding the complex interactions as to how ES adapts to changing biochemical changes within the tumor microenvironment.https://www.mdpi.com/2072-6694/14/8/1988Ewing sarcomaprogressiontargeted therapy<i>EWSR1/FLI1</i> |
| spellingShingle | Daria Fayzullina Sergey Tsibulnikov Mikhail Stempen Brett A. Schroeder Naveen Kumar Rajesh Kumar Kharwar Arbind Acharya Peter Timashev Ilya Ulasov Novel Targeted Therapeutic Strategies for Ewing Sarcoma Cancers Ewing sarcoma progression targeted therapy <i>EWSR1/FLI1</i> |
| title | Novel Targeted Therapeutic Strategies for Ewing Sarcoma |
| title_full | Novel Targeted Therapeutic Strategies for Ewing Sarcoma |
| title_fullStr | Novel Targeted Therapeutic Strategies for Ewing Sarcoma |
| title_full_unstemmed | Novel Targeted Therapeutic Strategies for Ewing Sarcoma |
| title_short | Novel Targeted Therapeutic Strategies for Ewing Sarcoma |
| title_sort | novel targeted therapeutic strategies for ewing sarcoma |
| topic | Ewing sarcoma progression targeted therapy <i>EWSR1/FLI1</i> |
| url | https://www.mdpi.com/2072-6694/14/8/1988 |
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