Synaptic remodeling follows upper motor neuron hyperexcitability in a rodent model of TDP-43

Synaptic remodeling follows upper motor neuron hyperexcitability in a rodent model of TDP-43

Amyotrophic Lateral Sclerosis (ALS) is an incurable disease characterized by relentlessly progressive degeneration of the corticomotor system. Cortical hyperexcitability has been identified as an early pre-symptomatic biomarker of ALS. This suggests that hyperexcitability occurs upstream in the ALS...

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Bibliographic Details
Main Authors: Marcus S. Dyer, G. Lorenzo Odierna, Rosemary M. Clark, Adele Woodhouse, Catherine A. Blizzard
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis
motor neuron disease
TDP-43
hyperexcitability
excitatory postsynaptic currents
synapse
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1274979/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1274979/full

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