LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation
Abstract Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC....
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13048-020-00689-6 |
| _version_ | 1797970407630831616 |
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| author | Kaiying Cui Genhai Zhu |
| author_facet | Kaiying Cui Genhai Zhu |
| author_sort | Kaiying Cui |
| collection | DOAJ |
| description | Abstract Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC. Result We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 in luciferase activity assay interacted with miR-216a, while overexpression of CTBP1-AS2 and miR-216a had no significant effects on the expression of each other. However, increased expression level of PTEN, a target of miR-216a, was observed after CTBP1-AS2 overexpression. Increased proliferation rate of OC cells was observed after the overexpression of miR-216a. CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. Conclusion CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation. |
| first_indexed | 2024-04-11T03:17:24Z |
| format | Article |
| id | doaj.art-a374301d0cf445f8b9ff1adf508742e3 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:17:24Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-a374301d0cf445f8b9ff1adf508742e32023-01-02T10:09:44ZengBMCJournal of Ovarian Research1757-22152020-07-011311610.1186/s13048-020-00689-6LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferationKaiying Cui0Genhai Zhu1Department of Gynaecology, Hainan People’s HospitalDepartment of Gynaecology, Hainan People’s HospitalAbstract Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC. Result We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 in luciferase activity assay interacted with miR-216a, while overexpression of CTBP1-AS2 and miR-216a had no significant effects on the expression of each other. However, increased expression level of PTEN, a target of miR-216a, was observed after CTBP1-AS2 overexpression. Increased proliferation rate of OC cells was observed after the overexpression of miR-216a. CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. Conclusion CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation.http://link.springer.com/article/10.1186/s13048-020-00689-6CTBP1-AS2Ovarian cancermiR-216aPTENProliferation |
| spellingShingle | Kaiying Cui Genhai Zhu LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation Journal of Ovarian Research CTBP1-AS2 Ovarian cancer miR-216a PTEN Proliferation |
| title | LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation |
| title_full | LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation |
| title_fullStr | LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation |
| title_full_unstemmed | LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation |
| title_short | LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation |
| title_sort | lncrna ctbp1 as2 regulates mir 216a pten to suppress ovarian cancer cell proliferation |
| topic | CTBP1-AS2 Ovarian cancer miR-216a PTEN Proliferation |
| url | http://link.springer.com/article/10.1186/s13048-020-00689-6 |
| work_keys_str_mv | AT kaiyingcui lncrnactbp1as2regulatesmir216aptentosuppressovariancancercellproliferation AT genhaizhu lncrnactbp1as2regulatesmir216aptentosuppressovariancancercellproliferation |