INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION
Abstract. Patients with exacerbation of chronic herpesvirus infection were subjected to immunocorrection therapy. In the course of treatment, time-dependent correlations were found between the changes in production of IFNγ, IL-1β and IL-6, and initial level of IFNγ. The patients with high initial co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/174 |
| _version_ | 1797198176469385216 |
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| author | O. O. Obukhova A. N. Trunov A. P. Shvajuk O. M. Gorbenko L. A. Trunova |
| author_facet | O. O. Obukhova A. N. Trunov A. P. Shvajuk O. M. Gorbenko L. A. Trunova |
| author_sort | O. O. Obukhova |
| collection | DOAJ |
| description | Abstract. Patients with exacerbation of chronic herpesvirus infection were subjected to immunocorrection therapy. In the course of treatment, time-dependent correlations were found between the changes in production of IFNγ, IL-1β and IL-6, and initial level of IFNγ. The patients with high initial concentrations of IFNγ did also exhibit above-normal initial IL-1Β and IL-6 values, as compared to appropriate parameters for a sub-group with low IFNγ levels. In the course of immunocorrection with Echinacea, all the patients showed increase in IFNγ levels. However, due to initially low IFNγ values, its increase was more pronounced than in persons with high background levels of IFNγ. Dynamics of IL-1Β decrease and changes in IL-6 concentrations were more expressed in cases of higher initial levels of these cytokines. The alterations revealed for IFNγ, IL-1Β and IL-6 levels confirm that immunocorrection with Echinacea causes reduced intensity of inflammation and activation of antiviral immune response. (Med. Immunol., 2008, vol. 10, N 2-3, pp 283-290). |
| first_indexed | 2024-03-08T05:51:50Z |
| format | Article |
| id | doaj.art-a37925d2b3ca4ba49beac27ad8744636 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:42Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a37925d2b3ca4ba49beac27ad87446362024-04-22T13:07:33ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01102-328329010.15789/1563-0625-2008-2-3-283-290171INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTIONO. O. Obukhova0A. N. Trunov1A. P. Shvajuk2O. M. Gorbenko3L. A. Trunova4ГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскAbstract. Patients with exacerbation of chronic herpesvirus infection were subjected to immunocorrection therapy. In the course of treatment, time-dependent correlations were found between the changes in production of IFNγ, IL-1β and IL-6, and initial level of IFNγ. The patients with high initial concentrations of IFNγ did also exhibit above-normal initial IL-1Β and IL-6 values, as compared to appropriate parameters for a sub-group with low IFNγ levels. In the course of immunocorrection with Echinacea, all the patients showed increase in IFNγ levels. However, due to initially low IFNγ values, its increase was more pronounced than in persons with high background levels of IFNγ. Dynamics of IL-1Β decrease and changes in IL-6 concentrations were more expressed in cases of higher initial levels of these cytokines. The alterations revealed for IFNγ, IL-1Β and IL-6 levels confirm that immunocorrection with Echinacea causes reduced intensity of inflammation and activation of antiviral immune response. (Med. Immunol., 2008, vol. 10, N 2-3, pp 283-290).https://www.mimmun.ru/mimmun/article/view/174herpesvirus infectionimmunocorrectioncytokinesifnγil-1βil-6 |
| spellingShingle | O. O. Obukhova A. N. Trunov A. P. Shvajuk O. M. Gorbenko L. A. Trunova INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION Медицинская иммунология herpesvirus infection immunocorrection cytokines ifnγ il-1β il-6 |
| title | INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION |
| title_full | INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION |
| title_fullStr | INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION |
| title_full_unstemmed | INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION |
| title_short | INTERRELATIONS OF CYTOKINE PRODUCTION IN THE COURSE OF IMMUNOCORRECTION WITH ECHINACEA FOR REACTIVATION OF HERPESVIRUS INFECTION |
| title_sort | interrelations of cytokine production in the course of immunocorrection with echinacea for reactivation of herpesvirus infection |
| topic | herpesvirus infection immunocorrection cytokines ifnγ il-1β il-6 |
| url | https://www.mimmun.ru/mimmun/article/view/174 |
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