Circular RNAs’ cap-independent translation protein and its roles in carcinomas
Abstract Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the imp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-021-01417-4 |
| _version_ | 1818915297152729088 |
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| author | Lian He Changfeng Man Shouyan Xiang Lin Yao Xiaoyan Wang Yu Fan |
| author_facet | Lian He Changfeng Man Shouyan Xiang Lin Yao Xiaoyan Wang Yu Fan |
| author_sort | Lian He |
| collection | DOAJ |
| description | Abstract Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation. |
| first_indexed | 2024-12-20T00:00:02Z |
| format | Article |
| id | doaj.art-a3795f7ae8844ce7af696fbf199851c1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-20T00:00:02Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-a3795f7ae8844ce7af696fbf199851c12022-12-21T20:00:52ZengBMCMolecular Cancer1476-45982021-09-0120111110.1186/s12943-021-01417-4Circular RNAs’ cap-independent translation protein and its roles in carcinomasLian He0Changfeng Man1Shouyan Xiang2Lin Yao3Xiaoyan Wang4Yu Fan5Cancer Institue, Affiliated People’s Hospital of Jiangsu UniversityCancer Institue, Affiliated People’s Hospital of Jiangsu UniversityCancer Institue, Affiliated People’s Hospital of Jiangsu UniversityCancer Institue, Affiliated People’s Hospital of Jiangsu UniversityDepartment of Gastroenterology, Affiliated Suqian First People’s Hospital of Nanjing Medical UniversityCancer Institue, Affiliated People’s Hospital of Jiangsu UniversityAbstract Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation.https://doi.org/10.1186/s12943-021-01417-4CarcinomaCircular RNATranslationCircRNA-derived protein |
| spellingShingle | Lian He Changfeng Man Shouyan Xiang Lin Yao Xiaoyan Wang Yu Fan Circular RNAs’ cap-independent translation protein and its roles in carcinomas Molecular Cancer Carcinoma Circular RNA Translation CircRNA-derived protein |
| title | Circular RNAs’ cap-independent translation protein and its roles in carcinomas |
| title_full | Circular RNAs’ cap-independent translation protein and its roles in carcinomas |
| title_fullStr | Circular RNAs’ cap-independent translation protein and its roles in carcinomas |
| title_full_unstemmed | Circular RNAs’ cap-independent translation protein and its roles in carcinomas |
| title_short | Circular RNAs’ cap-independent translation protein and its roles in carcinomas |
| title_sort | circular rnas cap independent translation protein and its roles in carcinomas |
| topic | Carcinoma Circular RNA Translation CircRNA-derived protein |
| url | https://doi.org/10.1186/s12943-021-01417-4 |
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