Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats
We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating human nutritional status. However, the question...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2013-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679013000037/type/journal_article |
| _version_ | 1811156010029547520 |
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| author | Katsumi Shibata Chisa Sugita Mitsue Sano Tsutomu Fukuwatari |
| author_facet | Katsumi Shibata Chisa Sugita Mitsue Sano Tsutomu Fukuwatari |
| author_sort | Katsumi Shibata |
| collection | DOAJ |
| description | We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating human nutritional status. However, the question arises as to whether the urinary excretion of B-group vitamins in animals or human subjects decreases immediately before they become B-group vitamin insufficient or when fed a diet low in vitamins. In the present study, rats were fed a vitamin-free diet for 5 d, and changes in the levels of B-group vitamins in urine and blood were monitored. Urinary excretion of vitamin B1, vitamin B2, 4-pyridoxic acid (a catabolite of vitamin B6), pantothenic acid, folate and biotin steeply decreased, and all of the values reached zero within 1–2 d. With respect to blood, the concentrations of only three of the eight B-group vitamins (vitamin B1, pyridoxal phosphate and biotin) decreased to 15 % (P < 0·0001), 7 % (P < 0·0001) and 2 % (P < 0·0001) on day 5, respectively, compared with the values at the beginning of the experiment. The decrease was more rapid and the changes were greater in the urine samples than in the blood samples. The present data complement our previous proposal that the urinary excretion of B-group vitamins reflects the nutritional status of these vitamins. |
| first_indexed | 2024-04-10T04:44:11Z |
| format | Article |
| id | doaj.art-a37aa9d57c3e45eda50748213bc83f13 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:11Z |
| publishDate | 2013-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-a37aa9d57c3e45eda50748213bc83f132023-03-09T12:38:39ZengCambridge University PressJournal of Nutritional Science2048-67902013-01-01210.1017/jns.2013.3Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in ratsKatsumi Shibata0Chisa Sugita1Mitsue Sano2Tsutomu Fukuwatari3Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, JapanDepartment of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, JapanDepartment of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, JapanDepartment of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, JapanWe have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating human nutritional status. However, the question arises as to whether the urinary excretion of B-group vitamins in animals or human subjects decreases immediately before they become B-group vitamin insufficient or when fed a diet low in vitamins. In the present study, rats were fed a vitamin-free diet for 5 d, and changes in the levels of B-group vitamins in urine and blood were monitored. Urinary excretion of vitamin B1, vitamin B2, 4-pyridoxic acid (a catabolite of vitamin B6), pantothenic acid, folate and biotin steeply decreased, and all of the values reached zero within 1–2 d. With respect to blood, the concentrations of only three of the eight B-group vitamins (vitamin B1, pyridoxal phosphate and biotin) decreased to 15 % (P < 0·0001), 7 % (P < 0·0001) and 2 % (P < 0·0001) on day 5, respectively, compared with the values at the beginning of the experiment. The decrease was more rapid and the changes were greater in the urine samples than in the blood samples. The present data complement our previous proposal that the urinary excretion of B-group vitamins reflects the nutritional status of these vitamins.https://www.cambridge.org/core/product/identifier/S2048679013000037/type/journal_articleVitaminsDeficiencyUrineBloodRats |
| spellingShingle | Katsumi Shibata Chisa Sugita Mitsue Sano Tsutomu Fukuwatari Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats Journal of Nutritional Science Vitamins Deficiency Urine Blood Rats |
| title | Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats |
| title_full | Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats |
| title_fullStr | Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats |
| title_full_unstemmed | Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats |
| title_short | Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats |
| title_sort | urinary excretion of b group vitamins reflects the nutritional status of b group vitamins in rats |
| topic | Vitamins Deficiency Urine Blood Rats |
| url | https://www.cambridge.org/core/product/identifier/S2048679013000037/type/journal_article |
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