Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats
We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-HT2 receptor antagonist on the discriminative...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319303743 |
| _version_ | 1818479316418166784 |
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| author | Kazumi Yoshizawa Tomohisa Mori Tamami Ueno Mizuki Nishiwaki Masahiro Shibasaki Norifumi Shimizu Minoru Narita Tsutomu Suzuki |
| author_facet | Kazumi Yoshizawa Tomohisa Mori Tamami Ueno Mizuki Nishiwaki Masahiro Shibasaki Norifumi Shimizu Minoru Narita Tsutomu Suzuki |
| author_sort | Kazumi Yoshizawa |
| collection | DOAJ |
| description | We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-HT2 receptor antagonist on the discriminative stimulus effects of ketamine in rats. While sulpiride did not attenuate the discriminative stimulus effects of ketamine, both clozapine and ketanserin attenuated those of ketamine, suggesting that the discriminative stimulus effects of ketamine are mediated by multiple receptors, especially the 5-HT2 receptor, but not the D2 receptor. Furthermore, our findings imply that atypical antipsychotics could be useful for the treatment of psychotomimetic effects induced by ketamine. Keywords:: atypical antipsychotic, 5-HT2 receptor, ketamine |
| first_indexed | 2024-12-10T11:08:59Z |
| format | Article |
| id | doaj.art-a37afac6470b4159b795d3b238a6ef8a |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-10T11:08:59Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-a37afac6470b4159b795d3b238a6ef8a2022-12-22T01:51:29ZengElsevierJournal of Pharmacological Sciences1347-86132013-01-011213237241Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in RatsKazumi Yoshizawa0Tomohisa Mori1Tamami Ueno2Mizuki Nishiwaki3Masahiro Shibasaki4Norifumi Shimizu5Minoru Narita6Tsutomu Suzuki7Department of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan; Corresponding author. suzuki@hoshi.ac.jpWe have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-HT2 receptor antagonist on the discriminative stimulus effects of ketamine in rats. While sulpiride did not attenuate the discriminative stimulus effects of ketamine, both clozapine and ketanserin attenuated those of ketamine, suggesting that the discriminative stimulus effects of ketamine are mediated by multiple receptors, especially the 5-HT2 receptor, but not the D2 receptor. Furthermore, our findings imply that atypical antipsychotics could be useful for the treatment of psychotomimetic effects induced by ketamine. Keywords:: atypical antipsychotic, 5-HT2 receptor, ketaminehttp://www.sciencedirect.com/science/article/pii/S1347861319303743 |
| spellingShingle | Kazumi Yoshizawa Tomohisa Mori Tamami Ueno Mizuki Nishiwaki Masahiro Shibasaki Norifumi Shimizu Minoru Narita Tsutomu Suzuki Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats Journal of Pharmacological Sciences |
| title | Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats |
| title_full | Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats |
| title_fullStr | Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats |
| title_full_unstemmed | Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats |
| title_short | Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats |
| title_sort | involvement of serotonin receptor mechanisms in the discriminative stimulus effects of ketamine in rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319303743 |
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