Immune Checkpoints in Viral Infections
As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism. Although immune checkpoint th...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/12/9/1051 |
| _version_ | 1827705802449747968 |
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| author | Huiming Cai Ge Liu Jianfeng Zhong Kai Zheng Haitao Xiao Chenyang Li Xun Song Ying Li Chenshu Xu Haiqiang Wu Zhendan He Qinchang Zhu |
| author_facet | Huiming Cai Ge Liu Jianfeng Zhong Kai Zheng Haitao Xiao Chenyang Li Xun Song Ying Li Chenshu Xu Haiqiang Wu Zhendan He Qinchang Zhu |
| author_sort | Huiming Cai |
| collection | DOAJ |
| description | As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism. Although immune checkpoint therapy has been successfully used in cancer treatment, numerous studies have suggested that such therapy may also be highly relevant for treating viral infection, especially chronic viral infections. However, it has not yet been applied in this manner. Here, we reviewed recent findings regarding immune checkpoints in viral infections, including COVID-19, and discussed the role of immune checkpoints in different viral infections, as well as the potential for applying immune checkpoint blockades as antiviral therapy. |
| first_indexed | 2024-03-10T16:10:53Z |
| format | Article |
| id | doaj.art-a37f4a18edc842d394578f6207b61094 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T16:10:53Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a37f4a18edc842d394578f6207b610942023-11-20T14:30:43ZengMDPI AGViruses1999-49152020-09-01129105110.3390/v12091051Immune Checkpoints in Viral InfectionsHuiming Cai0Ge Liu1Jianfeng Zhong2Kai Zheng3Haitao Xiao4Chenyang Li5Xun Song6Ying Li7Chenshu Xu8Haiqiang Wu9Zhendan He10Qinchang Zhu11Guangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaGuangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaAs evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism. Although immune checkpoint therapy has been successfully used in cancer treatment, numerous studies have suggested that such therapy may also be highly relevant for treating viral infection, especially chronic viral infections. However, it has not yet been applied in this manner. Here, we reviewed recent findings regarding immune checkpoints in viral infections, including COVID-19, and discussed the role of immune checkpoints in different viral infections, as well as the potential for applying immune checkpoint blockades as antiviral therapy.https://www.mdpi.com/1999-4915/12/9/1051immune checkpointviruschronic infectionimmunotherapy |
| spellingShingle | Huiming Cai Ge Liu Jianfeng Zhong Kai Zheng Haitao Xiao Chenyang Li Xun Song Ying Li Chenshu Xu Haiqiang Wu Zhendan He Qinchang Zhu Immune Checkpoints in Viral Infections Viruses immune checkpoint virus chronic infection immunotherapy |
| title | Immune Checkpoints in Viral Infections |
| title_full | Immune Checkpoints in Viral Infections |
| title_fullStr | Immune Checkpoints in Viral Infections |
| title_full_unstemmed | Immune Checkpoints in Viral Infections |
| title_short | Immune Checkpoints in Viral Infections |
| title_sort | immune checkpoints in viral infections |
| topic | immune checkpoint virus chronic infection immunotherapy |
| url | https://www.mdpi.com/1999-4915/12/9/1051 |
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