sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis

sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis

Abstract Background About 90% of cancer-related deaths are due to metastasis of cancer cells, and angiogenesis is a critical step in this process. sFLT01 is a novel fusion protein and a dual-targeting agent that neutralizes both VEGF and PlGF proangiogenic activities. GRP78 dual effect in tumor grow...

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Bibliographic Details
Main Authors: Sepideh Taghizadeh, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Ali Kashanian, Fahimeh Zakeri, Hamid Latifi-Navid, Hoda Shams Najafabadi
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Molecular and Cell Biology
Subjects:
Prostate cancer
Angiogenesis
sFLT01
VEGF
GRP78
Online Access:https://doi.org/10.1186/s12860-021-00367-5

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