Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination

Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination

Abstract Background HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such as DCAF1-Cul4A E3 ligase complex) to t...

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Bibliographic Details
Main Authors: Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug, Laurence Briant
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Translational Medicine
Subjects:
Uracil DNA glycosylase 2
Human immunodeficiency virus
Vpr
Uracilation
Class switch recombination
Online Access:http://link.springer.com/article/10.1186/s12967-020-02478-7

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