Newly identified roles of PML in stem cell biology
It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute promyelocytic leukemia (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00050/full |
| _version_ | 1818518776975458304 |
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| author | Keisuke eIto Kyoko eIto |
| author_facet | Keisuke eIto Kyoko eIto |
| author_sort | Keisuke eIto |
| collection | DOAJ |
| description | It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute promyelocytic leukemia (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprogramming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical ‘rheostat’ responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications. |
| first_indexed | 2024-12-11T01:14:54Z |
| format | Article |
| id | doaj.art-a381f0a4548e4d94b69c137292bbb401 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T01:14:54Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a381f0a4548e4d94b69c137292bbb4012022-12-22T01:25:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-03-01310.3389/fonc.2013.0005044739Newly identified roles of PML in stem cell biologyKeisuke eIto0Kyoko eIto1Albert Einstein College of MedicineAlbert Einstein College of MedicineIt has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute promyelocytic leukemia (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprogramming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical ‘rheostat’ responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00050/fullMetabolismStem Cellsbreast cancerstem cells and differentiationPML |
| spellingShingle | Keisuke eIto Kyoko eIto Newly identified roles of PML in stem cell biology Frontiers in Oncology Metabolism Stem Cells breast cancer stem cells and differentiation PML |
| title | Newly identified roles of PML in stem cell biology |
| title_full | Newly identified roles of PML in stem cell biology |
| title_fullStr | Newly identified roles of PML in stem cell biology |
| title_full_unstemmed | Newly identified roles of PML in stem cell biology |
| title_short | Newly identified roles of PML in stem cell biology |
| title_sort | newly identified roles of pml in stem cell biology |
| topic | Metabolism Stem Cells breast cancer stem cells and differentiation PML |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00050/full |
| work_keys_str_mv | AT keisukeeito newlyidentifiedrolesofpmlinstemcellbiology AT kyokoeito newlyidentifiedrolesofpmlinstemcellbiology |