Histological changes in neonatal sepsis
One of the most significant causes of neonatal morbidity and mortality is represented by neonatal sepsis that often manifests itself as a systemic inflammatory response syndrome (SIRS). The progression of SIRS usually leads to multiple organ dysfunction, occasionally culminating in multiple organ fa...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hygeia Press di Corridori Marinella
2014-10-01
|
| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/218 |
| _version_ | 1828961659068088320 |
|---|---|
| author | Eleonora Obinu Vassilios Fanos Clara Gerosa Daniela Fanni Cristina Loddo Rossano Ambu Gavino Faa |
| author_facet | Eleonora Obinu Vassilios Fanos Clara Gerosa Daniela Fanni Cristina Loddo Rossano Ambu Gavino Faa |
| author_sort | Eleonora Obinu |
| collection | DOAJ |
| description | One of the most significant causes of neonatal morbidity and mortality is represented by neonatal sepsis that often manifests itself as a systemic inflammatory response syndrome (SIRS). The progression of SIRS usually leads to multiple organ dysfunction, occasionally culminating in multiple organ failure (MOF).
The loss of endothelial barrier represents the unifying lesion of multiple organs in newborns affected by sepsis and the most important pathological change responsible for the evolution toward MOF in neonates.
The aim of this study is to present the most important pathological changes occurring in neonatal sepsis.
Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving
Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken |
| first_indexed | 2024-12-14T09:49:24Z |
| format | Article |
| id | doaj.art-a382b2e401f84f80a2448500a8c667ca |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-14T09:49:24Z |
| publishDate | 2014-10-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-a382b2e401f84f80a2448500a8c667ca2022-12-21T23:07:33ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922014-10-0132e030266e03026610.7363/030266180Histological changes in neonatal sepsisEleonora Obinu0Vassilios Fanos1Clara Gerosa2Daniela Fanni3Cristina Loddo4Rossano Ambu5Gavino Faa6Department of Pathology, University of Cagliari, Cagliari, ItalyNeonatal Intensive Care Unit, Neonatal Pathology, Puericulture Institute and Neonatal Section, AOU and University of Cagliari, Cagliari, ItalyDepartment of Pathology, University of Cagliari, Cagliari, ItalyDepartment of Pathology, University of Cagliari, Cagliari, ItalyNeonatal Intensive Care Unit, Neonatal Pathology, Puericulture Institute and Neonatal Section, AOU and University of Cagliari, Cagliari, ItalyDepartment of Pathology, University of Cagliari, Cagliari, ItalyDepartment of Pathology, University of Cagliari, Cagliari, ItalyOne of the most significant causes of neonatal morbidity and mortality is represented by neonatal sepsis that often manifests itself as a systemic inflammatory response syndrome (SIRS). The progression of SIRS usually leads to multiple organ dysfunction, occasionally culminating in multiple organ failure (MOF). The loss of endothelial barrier represents the unifying lesion of multiple organs in newborns affected by sepsis and the most important pathological change responsible for the evolution toward MOF in neonates. The aim of this study is to present the most important pathological changes occurring in neonatal sepsis. Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eykenhttps://www.jpnim.com/index.php/jpnim/article/view/218neonatal sepsismofendothelial damageloss of podocytesendothelial apoptosis |
| spellingShingle | Eleonora Obinu Vassilios Fanos Clara Gerosa Daniela Fanni Cristina Loddo Rossano Ambu Gavino Faa Histological changes in neonatal sepsis Journal of Pediatric and Neonatal Individualized Medicine neonatal sepsis mof endothelial damage loss of podocytes endothelial apoptosis |
| title | Histological changes in neonatal sepsis |
| title_full | Histological changes in neonatal sepsis |
| title_fullStr | Histological changes in neonatal sepsis |
| title_full_unstemmed | Histological changes in neonatal sepsis |
| title_short | Histological changes in neonatal sepsis |
| title_sort | histological changes in neonatal sepsis |
| topic | neonatal sepsis mof endothelial damage loss of podocytes endothelial apoptosis |
| url | https://www.jpnim.com/index.php/jpnim/article/view/218 |
| work_keys_str_mv | AT eleonoraobinu histologicalchangesinneonatalsepsis AT vassiliosfanos histologicalchangesinneonatalsepsis AT claragerosa histologicalchangesinneonatalsepsis AT danielafanni histologicalchangesinneonatalsepsis AT cristinaloddo histologicalchangesinneonatalsepsis AT rossanoambu histologicalchangesinneonatalsepsis AT gavinofaa histologicalchangesinneonatalsepsis |