Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia
B-cell acute lymphocytic leukemia (B-ALL) is the main neoplasia affecting children worldwide, in which cytotoxic chemotherapy remains the main treatment modality. In this study, we analyzed the profile of inflammatory markers concerning oxidative stress and cytokines in 17 B-ALL patients. Peripheral...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Current Research in Immunology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590255521000172 |
| _version_ | 1819004771168681984 |
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| author | G.E. Broto P.R.B. Silva F.C. Trigo V.J. Victorino K.L. Bonifácio W.R. Pavanelli F. Tomiotto-Pelissier M.R. Garbim S.T. Oliveira J.J. Jumes C. Panis D.S. Barbosa |
| author_facet | G.E. Broto P.R.B. Silva F.C. Trigo V.J. Victorino K.L. Bonifácio W.R. Pavanelli F. Tomiotto-Pelissier M.R. Garbim S.T. Oliveira J.J. Jumes C. Panis D.S. Barbosa |
| author_sort | G.E. Broto |
| collection | DOAJ |
| description | B-cell acute lymphocytic leukemia (B-ALL) is the main neoplasia affecting children worldwide, in which cytotoxic chemotherapy remains the main treatment modality. In this study, we analyzed the profile of inflammatory markers concerning oxidative stress and cytokines in 17 B-ALL patients. Peripheral blood (PB) and bone marrow (BM) samples were collected and evaluated for the pro-oxidative status (nitric oxide products-NOx and hydroperoxides), antioxidants (sulfhydryl groups-SH and total radical-trapping antioxidant parameter-TRAP), and cytokines (TNF-α, IFN-γ), at diagnosis (D0) to and the end of the induction phase (D28). At D28, hydroperoxides were higher in PB, concomitant to TNF-α levels. INF-γ was increased in the BM at D28. Hydroperoxides were higher in patients presenting malignant cells in BM and/or PB after treatment, a condition named minimal residual disease (MRD) when compared to those without MRD at D28. These findings suggest that oxidative stress and cytokines vary across the B-ALL induction phase, and lipid peroxidation is a potential marker associated with MRD status. |
| first_indexed | 2024-12-20T23:42:11Z |
| format | Article |
| id | doaj.art-a3836e819f264b9c86a1f20e5e3ea44b |
| institution | Directory Open Access Journal |
| issn | 2590-2555 |
| language | English |
| last_indexed | 2024-12-20T23:42:11Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Immunology |
| spelling | doaj.art-a3836e819f264b9c86a1f20e5e3ea44b2022-12-21T19:23:03ZengElsevierCurrent Research in Immunology2590-25552021-01-012163168Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemiaG.E. Broto0P.R.B. Silva1F.C. Trigo2V.J. Victorino3K.L. Bonifácio4W.R. Pavanelli5F. Tomiotto-Pelissier6M.R. Garbim7S.T. Oliveira8J.J. Jumes9C. Panis10D.S. Barbosa11Health Sciences Postgraduate Program, State University of Londrina (UEL), Londrina, PR, BrazilHealth Sciences Postgraduate Program, State University of Londrina (UEL), Londrina, PR, BrazilLondrina Cancer Institute, Londrina, Paraná, BrazilFederal Institute of Rio de Janeiro, Rio de Janeiro, BrazilHealth Sciences Postgraduate Program, State University of Londrina (UEL), Londrina, PR, BrazilExperimental Pathology Postgraduate Program, State University of Londrina (UEL), Londrina, PR, BrazilExperimental Pathology Postgraduate Program, State University of Londrina (UEL), Londrina, PR, Brazil; Carlos Chagas Institute, Curitiba, Paraná, BrazilLaboratory of Tumor Biology, State University of Western Paraná (UNIOESTE), Francisco Beltrão, PR, BrazilLaboratory of Tumor Biology, State University of Western Paraná (UNIOESTE), Francisco Beltrão, PR, BrazilLaboratory of Tumor Biology, State University of Western Paraná (UNIOESTE), Francisco Beltrão, PR, Brazil; Health Sciences Postgraduate Program, State University of Western Paraná (UNIOESTE), Francisco Beltrão, PR, BrazilLaboratory of Tumor Biology, State University of Western Paraná (UNIOESTE), Francisco Beltrão, PR, Brazil; Health Sciences Postgraduate Program, State University of Western Paraná (UNIOESTE), Francisco Beltrão, PR, Brazil; Experimental Pathology Postgraduate Program, State University of Londrina (UEL), Londrina, PR, Brazil; Corresponding author. Universidade Estadual do Oeste do Paraná Centro de Ciências da Saúde – Laboratório de Biologia de Tumores Rodovia Vitório Traiano, Km2 – Água Branca Francisco Beltrão, Paraná, Brazil.Health Sciences Postgraduate Program, State University of Londrina (UEL), Londrina, PR, BrazilB-cell acute lymphocytic leukemia (B-ALL) is the main neoplasia affecting children worldwide, in which cytotoxic chemotherapy remains the main treatment modality. In this study, we analyzed the profile of inflammatory markers concerning oxidative stress and cytokines in 17 B-ALL patients. Peripheral blood (PB) and bone marrow (BM) samples were collected and evaluated for the pro-oxidative status (nitric oxide products-NOx and hydroperoxides), antioxidants (sulfhydryl groups-SH and total radical-trapping antioxidant parameter-TRAP), and cytokines (TNF-α, IFN-γ), at diagnosis (D0) to and the end of the induction phase (D28). At D28, hydroperoxides were higher in PB, concomitant to TNF-α levels. INF-γ was increased in the BM at D28. Hydroperoxides were higher in patients presenting malignant cells in BM and/or PB after treatment, a condition named minimal residual disease (MRD) when compared to those without MRD at D28. These findings suggest that oxidative stress and cytokines vary across the B-ALL induction phase, and lipid peroxidation is a potential marker associated with MRD status.http://www.sciencedirect.com/science/article/pii/S2590255521000172B-cell acute lymphocytic leukemiaCytokinesOxidative stressPrognosisMinimal residual diseaseHydroperoxides |
| spellingShingle | G.E. Broto P.R.B. Silva F.C. Trigo V.J. Victorino K.L. Bonifácio W.R. Pavanelli F. Tomiotto-Pelissier M.R. Garbim S.T. Oliveira J.J. Jumes C. Panis D.S. Barbosa Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia Current Research in Immunology B-cell acute lymphocytic leukemia Cytokines Oxidative stress Prognosis Minimal residual disease Hydroperoxides |
| title | Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_full | Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_fullStr | Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_full_unstemmed | Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_short | Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_sort | impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| topic | B-cell acute lymphocytic leukemia Cytokines Oxidative stress Prognosis Minimal residual disease Hydroperoxides |
| url | http://www.sciencedirect.com/science/article/pii/S2590255521000172 |
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