A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers

<p>Abstract</p> <p>Background</p> <p>The development of resistance to hormone therapy in both breast and prostate cancers is attributed to tens of thousands of patient deaths every year.</p> <p>Results</p> <p>From analyses of global gene expressi...

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Main Author: Creighton Chad J
Format: Article
Language:English
Published: BMC 2007-06-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/8/199
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author Creighton Chad J
author_facet Creighton Chad J
author_sort Creighton Chad J
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>The development of resistance to hormone therapy in both breast and prostate cancers is attributed to tens of thousands of patient deaths every year.</p> <p>Results</p> <p>From analyses of global gene expression profile data, a nonrandom amount of overlap was observed between the set of genes associated with estrogen receptor negative (ER-), hormone independent breast cancer and the set of genes associated with androgen independent (AI) prostate cancer. A set of 81 genes was identified that were differentially expressed between ER- and ER+ clinical breast tumors and breast cancer cell lines and that showed concordant expression in AI versus AS (androgen sensitive) prostate cell lines. This common gene signature of hormone independence was used to identify a subset of clinically localized primary prostate tumors that shared extensive similarities in gene transcription with both ER- breast and AI prostate cell lines and that tended to show concurrent deactivation of the androgen signaling pathway. Both ER- breast and AI prostate cell lines were significantly enriched for transcriptional targets of signaling via epidermal growth factor receptor (EGFR).</p> <p>Conclusion</p> <p>This study indicates that the growth- and survival-promoting functions of hormone receptors can be bypassed in a subset of both breast and prostate cancers by the same growth factor signaling pathways, which holds implications for the use of targeted therapy regimens.</p>
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spelling doaj.art-a38403105abb42c48d47485834ae4f912022-12-21T23:16:54ZengBMCBMC Genomics1471-21642007-06-018119910.1186/1471-2164-8-199A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancersCreighton Chad J<p>Abstract</p> <p>Background</p> <p>The development of resistance to hormone therapy in both breast and prostate cancers is attributed to tens of thousands of patient deaths every year.</p> <p>Results</p> <p>From analyses of global gene expression profile data, a nonrandom amount of overlap was observed between the set of genes associated with estrogen receptor negative (ER-), hormone independent breast cancer and the set of genes associated with androgen independent (AI) prostate cancer. A set of 81 genes was identified that were differentially expressed between ER- and ER+ clinical breast tumors and breast cancer cell lines and that showed concordant expression in AI versus AS (androgen sensitive) prostate cell lines. This common gene signature of hormone independence was used to identify a subset of clinically localized primary prostate tumors that shared extensive similarities in gene transcription with both ER- breast and AI prostate cell lines and that tended to show concurrent deactivation of the androgen signaling pathway. Both ER- breast and AI prostate cell lines were significantly enriched for transcriptional targets of signaling via epidermal growth factor receptor (EGFR).</p> <p>Conclusion</p> <p>This study indicates that the growth- and survival-promoting functions of hormone receptors can be bypassed in a subset of both breast and prostate cancers by the same growth factor signaling pathways, which holds implications for the use of targeted therapy regimens.</p>http://www.biomedcentral.com/1471-2164/8/199
spellingShingle Creighton Chad J
A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
BMC Genomics
title A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
title_full A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
title_fullStr A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
title_full_unstemmed A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
title_short A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
title_sort gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
url http://www.biomedcentral.com/1471-2164/8/199
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