Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
Deubiquitinase (DUB) is an essential component in the ubiquitin—proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising progn...
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MDPI AG
2021-09-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/9/965 |
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| author | Sixuan Li Hongquan Zhang Xiaofan Wei |
| author_facet | Sixuan Li Hongquan Zhang Xiaofan Wei |
| author_sort | Sixuan Li |
| collection | DOAJ |
| description | Deubiquitinase (DUB) is an essential component in the ubiquitin—proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising prognostic indicators and drug targets. DUBs have shown significant roles in regulating breast cancer growth, metastasis, resistance to current therapies, and several canonical oncogenic signaling pathways. In addition, specific DUB inhibitors have been identified and are expected to benefit breast cancer patients in the future. Here, we review current knowledge about the effects and molecular mechanisms of DUBs in breast cancer, providing novel insight into treatments of breast cancer-targeting DUBs. |
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| id | doaj.art-a3844beb441046f49b5822f6169621df |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T07:30:11Z |
| publishDate | 2021-09-01 |
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| spelling | doaj.art-a3844beb441046f49b5822f6169621df2023-11-22T13:56:35ZengMDPI AGLife2075-17292021-09-0111996510.3390/life11090965Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug DiscoverySixuan Li0Hongquan Zhang1Xiaofan Wei2Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Unversity Health Science Center, Beijing 100191, ChinaDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Unversity Health Science Center, Beijing 100191, ChinaDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Unversity Health Science Center, Beijing 100191, ChinaDeubiquitinase (DUB) is an essential component in the ubiquitin—proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising prognostic indicators and drug targets. DUBs have shown significant roles in regulating breast cancer growth, metastasis, resistance to current therapies, and several canonical oncogenic signaling pathways. In addition, specific DUB inhibitors have been identified and are expected to benefit breast cancer patients in the future. Here, we review current knowledge about the effects and molecular mechanisms of DUBs in breast cancer, providing novel insight into treatments of breast cancer-targeting DUBs.https://www.mdpi.com/2075-1729/11/9/965deubiquitinasebreast cancertumor growth and metastasiscancer therapy |
| spellingShingle | Sixuan Li Hongquan Zhang Xiaofan Wei Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery Life deubiquitinase breast cancer tumor growth and metastasis cancer therapy |
| title | Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery |
| title_full | Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery |
| title_fullStr | Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery |
| title_full_unstemmed | Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery |
| title_short | Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery |
| title_sort | roles and mechanisms of deubiquitinases dubs in breast cancer progression and targeted drug discovery |
| topic | deubiquitinase breast cancer tumor growth and metastasis cancer therapy |
| url | https://www.mdpi.com/2075-1729/11/9/965 |
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